3-(N-(dimethylaminomethylene)carbamoyl)-8-benzyloxypyrazolo[5,1-c][1,2,4] benzotriazine 5-oxide

Base Information

• Chemical Name: 3-(N-(dimethylaminomethylene)carbamoyl)-8-benzyloxypyrazolo[5,1-c][1,2,4] benzotriazine 5-oxide
• CAS No.: 1428986-47-3
• Molecular Formula: C₂₀H₁₈N₆O₃
• Molecular Weight: 390.401
• Mol file: 1428986-47-3.mol

Synonyms:3-(N-(dimethylaminomethylene)carbamoyl)-8-benzyloxypyrazolo[5,1-c][1,2,4] benzotriazine 5-oxide

Chemical Property of 3-(N-(dimethylaminomethylene)carbamoyl)-8-benzyloxypyrazolo[5,1-c][1,2,4] benzotriazine 5-oxide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-(N-(dimethylaminomethylene)carbamoyl)-8-benzyloxypyrazolo[5,1-c][1,2,4] benzotriazine 5-oxide

There total 3 articles about 3-(N-(dimethylaminomethylene)carbamoyl)-8-benzyloxypyrazolo[5,1-c][1,2,4] benzotriazine 5-oxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

3-Carbamoyl-8-benzyloxypyrazolo[5,1-c][1,2,4]benzotriazine 5-oxide (1428986-41-7) + N,N-dimethyl-formamide dimethyl acetal (4637-24-5) → 3-(N-(dimethylaminomethylene)carbamoyl)-8-benzyloxypyrazolo[5,1-c][1,2,4] benzotriazine 5-oxide (1428986-47-3)

Guidance literature:

With dimethylacetale; In toluene; at 100 - 110 ℃; for 2h;

DOI:10.1016/j.bmc.2013.02.027

Reference yield:

3-carbamoyl-8-chloropyrazolo-<5,1-c><1,2,4>benzotriazine 5-oxide (161464-32-0) → 3-(N-(dimethylaminomethylene)carbamoyl)-8-benzyloxypyrazolo[5,1-c][1,2,4] benzotriazine 5-oxide (1428986-47-3)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hydroxide; tetrabutylammomium bromide / water; dichloromethane

2: dimethylacetale / toluene / 2 h / 100 - 110 °C

With tetrabutylammomium bromide; sodium hydroxide; In dichloromethane; water; toluene;

DOI:10.1016/j.bmc.2013.02.027

Reference yield:

benzyl alcohol (100-51-6,185532-71-2) → 3-(N-(dimethylaminomethylene)carbamoyl)-8-benzyloxypyrazolo[5,1-c][1,2,4] benzotriazine 5-oxide (1428986-47-3)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hydroxide; tetrabutylammomium bromide / water; dichloromethane

2: dimethylacetale / toluene / 2 h / 100 - 110 °C

With tetrabutylammomium bromide; sodium hydroxide; In dichloromethane; water; toluene;

DOI:10.1016/j.bmc.2013.02.027

upstream raw materials:

3-Carbamoyl-8-benzyloxypyrazolo[5,1-c][1,2,4]benzotriazine 5-oxide

N,N-dimethyl-formamide dimethyl acetal

3-carbamoyl-8-chloropyrazolo-<5,1-c><1,2,4>benzotriazine 5-oxide

benzyl alcohol

Downstream raw materials:

3-(1,2,4-Triazol-3-yl)-8-benzyloxypyrazolo[5,1-c][1,2,4]benzotriazine 5-oxide

C₁₉H₁₅N₇O₂

C₁₉H₁₅N₇O₂