methyl {[(1-benzyl-1H-tetrazol-5-yl){4-[2-(3-methyl-3H-diaziren-3-yl)ethoxy]phenyl}methyl](2-propyn-1-yl)amino}acetate

Base Information

Chemical Name:methyl {[(1-benzyl-1H-tetrazol-5-yl){4-[2-(3-methyl-3H-diaziren-3-yl)ethoxy]phenyl}methyl](2-propyn-1-yl)amino}acetate
CAS No.:1620482-84-9
Molecular Formula:C₂₅H₂₇N₇O₃
Molecular Weight:473.534
Hs Code.:

Synonyms:methyl {[(1-benzyl-1H-tetrazol-5-yl){4-[2-(3-methyl-3H-diaziren-3-yl)ethoxy]phenyl}methyl](2-propyn-1-yl)amino}acetate

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Chemical Property of methyl {[(1-benzyl-1H-tetrazol-5-yl){4-[2-(3-methyl-3H-diaziren-3-yl)ethoxy]phenyl}methyl](2-propyn-1-yl)amino}acetate

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Technology Process of methyl {[(1-benzyl-1H-tetrazol-5-yl){4-[2-(3-methyl-3H-diaziren-3-yl)ethoxy]phenyl}methyl](2-propyn-1-yl)amino}acetate

There total 3 articles about methyl {[(1-benzyl-1H-tetrazol-5-yl){4-[2-(3-methyl-3H-diaziren-3-yl)ethoxy]phenyl}methyl](2-propyn-1-yl)amino}acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.0%

: 1620482-54-3
N-[(1-benzyl-1H-tetrazol-5-yl){4-[2-(3-methyl-3H-diaziren-3-yl)ethoxy]phenyl}methyl]-2-propyn-1-amine

: 96-32-2
bromoacetic acid methyl ester

: 1620482-84-9
methyl {[(1-benzyl-1H-tetrazol-5-yl){4-[2-(3-methyl-3H-diaziren-3-yl)ethoxy]phenyl}methyl](2-propyn-1-yl)amino}acetate

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 80 ℃; for 16h; Inert atmosphere;
DOI:10.1021/ja505517t

Reference yield:

: 1620483-11-5
{4-[2-(3-methyl-3H-diaziren-3-yl)ethoxy]phenyl}methanol

: 1620482-84-9
methyl {[(1-benzyl-1H-tetrazol-5-yl){4-[2-(3-methyl-3H-diaziren-3-yl)ethoxy]phenyl}methyl](2-propyn-1-yl)amino}acetate

Guidance literature:: Multi-step reaction with 3 steps

1: sulfur trioxide pyridine complex; triethylamine / ethyl acetate; dimethyl sulfoxide / 0.33 h / 0 - 20 °C / Inert atmosphere

2: trimethylsilylazide / methanol / 0 - 20 °C / Inert atmosphere

3: potassium carbonate / N,N-dimethyl-formamide / 16 h / 80 °C / Inert atmosphere

With trimethylsilylazide; sulfur trioxide pyridine complex; potassium carbonate; triethylamine; In methanol; dimethyl sulfoxide; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/ja505517t

Reference yield:

: 1620483-12-6
4-[2-(3-methyl-3H-diaziren-3-yl)ethoxy]benzaldehyde

: 1620482-84-9
methyl {[(1-benzyl-1H-tetrazol-5-yl){4-[2-(3-methyl-3H-diaziren-3-yl)ethoxy]phenyl}methyl](2-propyn-1-yl)amino}acetate

Guidance literature:: Multi-step reaction with 2 steps

1: trimethylsilylazide / methanol / 0 - 20 °C / Inert atmosphere

2: potassium carbonate / N,N-dimethyl-formamide / 16 h / 80 °C / Inert atmosphere

With trimethylsilylazide; potassium carbonate; In methanol; N,N-dimethyl-formamide;
DOI:10.1021/ja505517t