N'-[9-[(1R,4R,6R,7S)-4-[[bis(4-methoxyphenyl)phenylmethoxy]methyl]-7-hydroxy-2,5-dioxabicyclo[2.2.1]heptan-6-yl]-6-oxo-1H-purin-2-yl]-N,N-dimethylformamidine

Base Information

Chemical Name:N'-[9-[(1R,4R,6R,7S)-4-[[bis(4-methoxyphenyl)phenylmethoxy]methyl]-7-hydroxy-2,5-dioxabicyclo[2.2.1]heptan-6-yl]-6-oxo-1H-purin-2-yl]-N,N-dimethylformamidine
CAS No.:206055-72-3
Molecular Formula:C₃₆H₃₇N₅O₈
Molecular Weight:667.718
Hs Code.:

N'-[9-[(1R,4R,6R,7S)-4-[[bis(4-methoxyphenyl)phenylmethoxy]methyl]-7-hydroxy-2,5-dioxabicyclo[2.2.1]heptan-6-yl]-6-oxo-1H-purin-2-yl]-N,N-dimethylformamidine

Synonyms:N'-[9-[(1R,4R,6R,7S)-4-[[bis(4-methoxyphenyl)phenylmethoxy]methyl]-7-hydroxy-2,5-dioxabicyclo[2.2.1]heptan-6-yl]-6-oxo-1H-purin-2-yl]-N,N-dimethylformamidine

Suppliers and Price of N'-[9-[(1R,4R,6R,7S)-4-[[bis(4-methoxyphenyl)phenylmethoxy]methyl]-7-hydroxy-2,5-dioxabicyclo[2.2.1]heptan-6-yl]-6-oxo-1H-purin-2-yl]-N,N-dimethylformamidine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Total 7 raw suppliers

Chemical Property of N'-[9-[(1R,4R,6R,7S)-4-[[bis(4-methoxyphenyl)phenylmethoxy]methyl]-7-hydroxy-2,5-dioxabicyclo[2.2.1]heptan-6-yl]-6-oxo-1H-purin-2-yl]-N,N-dimethylformamidine

Chemical Property:

Purity/Quality:: 97% ^*data from raw suppliers

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Hazard Codes:

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Technology Process of N'-[9-[(1R,4R,6R,7S)-4-[[bis(4-methoxyphenyl)phenylmethoxy]methyl]-7-hydroxy-2,5-dioxabicyclo[2.2.1]heptan-6-yl]-6-oxo-1H-purin-2-yl]-N,N-dimethylformamidine

There total 9 articles about N'-[9-[(1R,4R,6R,7S)-4-[[bis(4-methoxyphenyl)phenylmethoxy]methyl]-7-hydroxy-2,5-dioxabicyclo[2.2.1]heptan-6-yl]-6-oxo-1H-purin-2-yl]-N,N-dimethylformamidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 40615-36-9
4,4'-dimethoxytrityl chloride

: 206055-68-7
(1S,3R,4R,7S)-7-hydroxy-1-hydroxymethyl-3-(2-N-isobutyrylguanin-9-yl)-2,5-dioxabicyclo[2.2.1]heptane

: 206055-72-3
N'-[9-[(1R,4R,6R,7S)-4-[[bis(4-methoxyphenyl)phenylmethoxy]methyl]-7-hydroxy-2,5-dioxabicyclo[2.2.1]heptan-6-yl]-6-oxo-1H-purin-2-yl]-N,N-dimethylformamidine

Guidance literature:: With pyridine;
DOI:10.1039/a708608c

Reference yield:

: 63593-03-3
1,2-O-isopropylidene-3-O-benzyl-4-hydroxymethyl-α-D-ribofuranose

: 206055-72-3
N'-[9-[(1R,4R,6R,7S)-4-[[bis(4-methoxyphenyl)phenylmethoxy]methyl]-7-hydroxy-2,5-dioxabicyclo[2.2.1]heptan-6-yl]-6-oxo-1H-purin-2-yl]-N,N-dimethylformamidine

Guidance literature:: Multi-step reaction with 9 steps

1: NaH / dimethylformamide

2: pyridine

3: AcOH

4: pyridine

5: 76 percent / N,O-bis(trimethylsilyl)acetamide, TMS triflate / 1,2-dichloro-ethane

6: 97 percent / NaOMe / methanol

7: 1.) TsCl, pyridine, 2.) NaH / 2.) DMF

8: 98 percent / H₂ / 20percent Pd(OH)2/C / ethanol

9: 93 percent / pyridine

With pyridine; N,O-bis-(trimethylsilyl)-acetamide; trimethylsilyl trifluoromethanesulfonate; hydrogen; sodium methylate; sodium hydride; acetic acid; p-toluenesulfonyl chloride; palladium dihydroxide; In methanol; ethanol; 1,2-dichloro-ethane; N,N-dimethyl-formamide;
DOI:10.1039/a708608c

Reference yield:

: 153186-10-8
((3aR,5R,6S,6aR)-6-(benzyloxy)-5-((benzyloxy)methyl)-2,2-dimethyltetrahydrofuro[2,3-d][1,3]dioxol-5-yl)methanol

: 206055-72-3
N'-[9-[(1R,4R,6R,7S)-4-[[bis(4-methoxyphenyl)phenylmethoxy]methyl]-7-hydroxy-2,5-dioxabicyclo[2.2.1]heptan-6-yl]-6-oxo-1H-purin-2-yl]-N,N-dimethylformamidine

Guidance literature:: Multi-step reaction with 8 steps

1: pyridine

2: AcOH

3: pyridine

4: 76 percent / N,O-bis(trimethylsilyl)acetamide, TMS triflate / 1,2-dichloro-ethane

5: 97 percent / NaOMe / methanol

6: 1.) TsCl, pyridine, 2.) NaH / 2.) DMF

7: 98 percent / H₂ / 20percent Pd(OH)2/C / ethanol

8: 93 percent / pyridine

With pyridine; N,O-bis-(trimethylsilyl)-acetamide; trimethylsilyl trifluoromethanesulfonate; hydrogen; sodium methylate; sodium hydride; acetic acid; p-toluenesulfonyl chloride; palladium dihydroxide; In methanol; ethanol; 1,2-dichloro-ethane;
DOI:10.1039/a708608c