C₃₃H₃₄N₄O₄S

Base Information

• Chemical Name: C₃₃H₃₄N₄O₄S
• CAS No.: 494857-73-7
• Molecular Formula: C₃₃H₃₄N₄O₄S
• Molecular Weight: 582.723
• Mol file: 494857-73-7.mol

Synonyms:C₃₃H₃₄N₄O₄S

Chemical Property of C₃₃H₃₄N₄O₄S

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₃₃H₃₄N₄O₄S

There total 14 articles about C₃₃H₃₄N₄O₄S which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-aminocyclobutane-1-carboxylic acid (22264-50-2) → C33H34N4O4S (494857-73-7)

Guidance literature:

Multi-step reaction with 3 steps

1: potassium phosphate / acetonitrile / 20 °C / Inert atmosphere

2: dimethyl sulfoxide / 20 °C / Inert atmosphere

3: water / 20 °C / Alkaline conditions; Inert atmosphere

With potassium phosphate; water; In dimethyl sulfoxide; acetonitrile;

DOI:10.1021/jm3006788

Reference yield:

Indole-6-carboxylic acid (1670-82-2,261352-47-0) → C33H34N4O4S (494857-73-7)

Guidance literature:

Multi-step reaction with 9 steps

1.1: potassium hydroxide / methanol; water / 21 h / 75 °C / Inert atmosphere

2.1: 20% Pd(OH)2/C; hydrogen / methanol / 18 h / 760.05 Torr / Inert atmosphere

3.1: potassium carbonate / N,N-dimethyl-formamide / 5 h / 20 °C / Inert atmosphere

3.2: 0 - 20 °C / Inert atmosphere

4.1: bromine; sodium acetate / Isopropyl acetate / 4 - 13 °C / Inert atmosphere

5.1: n-butyllithium / tetrahydrofuran; hexane / 0.17 h / -71 °C / Inert atmosphere

5.2: -69 - 20 °C / Inert atmosphere

6.1: palladium diacetate; potassium carbonate; Tri(p-tolyl)phosphine / tetrahydrofuran; methanol; hexane / 4.5 h / Inert atmosphere; Reflux

7.1: water; sodium hydroxide / tetrahydrofuran; methanol / 60 °C / Inert atmosphere

8.1: dimethyl sulfoxide / 20 °C / Inert atmosphere

9.1: water / 20 °C / Alkaline conditions; Inert atmosphere

With n-butyllithium; 20% Pd(OH)2/C; water; hydrogen; bromine; sodium acetate; palladium diacetate; potassium carbonate; Tri(p-tolyl)phosphine; potassium hydroxide; sodium hydroxide; In tetrahydrofuran; methanol; hexane; Isopropyl acetate; water; dimethyl sulfoxide; N,N-dimethyl-formamide; 6.1: |Suzuki-Miyaura Coupling;

DOI:10.1021/jm3006788

Reference yield:

cyclopentanone (120-92-3) → C33H34N4O4S (494857-73-7)

Guidance literature:

Multi-step reaction with 9 steps

1.1: potassium hydroxide / methanol; water / 21 h / 75 °C / Inert atmosphere

2.1: 20% Pd(OH)2/C; hydrogen / methanol / 18 h / 760.05 Torr / Inert atmosphere

3.1: potassium carbonate / N,N-dimethyl-formamide / 5 h / 20 °C / Inert atmosphere

3.2: 0 - 20 °C / Inert atmosphere

4.1: bromine; sodium acetate / Isopropyl acetate / 4 - 13 °C / Inert atmosphere

5.1: n-butyllithium / tetrahydrofuran; hexane / 0.17 h / -71 °C / Inert atmosphere

5.2: -69 - 20 °C / Inert atmosphere

6.1: palladium diacetate; potassium carbonate; Tri(p-tolyl)phosphine / tetrahydrofuran; methanol; hexane / 4.5 h / Inert atmosphere; Reflux

7.1: water; sodium hydroxide / tetrahydrofuran; methanol / 60 °C / Inert atmosphere

8.1: dimethyl sulfoxide / 20 °C / Inert atmosphere

9.1: water / 20 °C / Alkaline conditions; Inert atmosphere

With n-butyllithium; 20% Pd(OH)2/C; water; hydrogen; bromine; sodium acetate; palladium diacetate; potassium carbonate; Tri(p-tolyl)phosphine; potassium hydroxide; sodium hydroxide; In tetrahydrofuran; methanol; hexane; Isopropyl acetate; water; dimethyl sulfoxide; N,N-dimethyl-formamide; 6.1: |Suzuki-Miyaura Coupling;

DOI:10.1021/jm3006788

upstream raw materials:

C₁₈H₁₈N₂O₂S

C₁₆H₂₀N₂O₃

Indole-6-carboxylic acid

cyclopentanone