(S)-ethyl 3-(1-(4-(hex-5-enyloxy)phenyl)-2-hydroxyethylamino)-2,2-dimethyl-3-oxopropanoate

Base Information

Chemical Name:(S)-ethyl 3-(1-(4-(hex-5-enyloxy)phenyl)-2-hydroxyethylamino)-2,2-dimethyl-3-oxopropanoate
CAS No.:1415547-29-3
Molecular Formula:C₂₁H₃₁NO₅
Molecular Weight:377.481
Hs Code.:

Synonyms:(S)-ethyl 3-(1-(4-(hex-5-enyloxy)phenyl)-2-hydroxyethylamino)-2,2-dimethyl-3-oxopropanoate

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Chemical Property of (S)-ethyl 3-(1-(4-(hex-5-enyloxy)phenyl)-2-hydroxyethylamino)-2,2-dimethyl-3-oxopropanoate

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Technology Process of (S)-ethyl 3-(1-(4-(hex-5-enyloxy)phenyl)-2-hydroxyethylamino)-2,2-dimethyl-3-oxopropanoate

There total 4 articles about (S)-ethyl 3-(1-(4-(hex-5-enyloxy)phenyl)-2-hydroxyethylamino)-2,2-dimethyl-3-oxopropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 5471-77-2
3-ethoxy-2,2-dimethyl-3-oxopropanoic acid

: 1415547-07-7
(S)-2-amino-2-(4-(hex-5-enyloxy)phenyl)ethanol

: 1415547-29-3
(S)-ethyl 3-(1-(4-(hex-5-enyloxy)phenyl)-2-hydroxyethylamino)-2,2-dimethyl-3-oxopropanoate

Guidance literature:: (S)-2-amino-2-(4-(hex-5-enyloxy)phenyl)ethanol; With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In chloroform; at 0 ℃; for 1.5h; Inert atmosphere;

3-ethoxy-2,2-dimethyl-3-oxopropanoic acid; In chloroform; at 20 ℃; for 18h; Inert atmosphere;
DOI:10.1016/j.tet.2012.10.069

Reference yield:

: 32462-30-9
(S)-hydroxyphenylglycine

: 1415547-29-3
(S)-ethyl 3-(1-(4-(hex-5-enyloxy)phenyl)-2-hydroxyethylamino)-2,2-dimethyl-3-oxopropanoate

Guidance literature:: Multi-step reaction with 4 steps

1.1: thionyl chloride / methanol / 16 h / 25 °C / Inert atmosphere

1.2: 16 h / 25 °C / Inert atmosphere

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 25 h / 0 - 20 °C / Inert atmosphere

3.1: potassium carbonate / acetone / 43 h / Inert atmosphere; Reflux

3.2: 27 h / 50 °C / Inert atmosphere

4.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / chloroform / 1.5 h / 0 °C / Inert atmosphere

4.2: 18 h / 20 °C / Inert atmosphere

With lithium aluminium tetrahydride; thionyl chloride; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; methanol; chloroform; acetone;
DOI:10.1016/j.tet.2012.10.069

Reference yield:

: 1415547-09-9
(S)-methyl 2-(4-hydroxyphenyl)-2-(methoxycarbonylamino)acetate

: 1415547-29-3
(S)-ethyl 3-(1-(4-(hex-5-enyloxy)phenyl)-2-hydroxyethylamino)-2,2-dimethyl-3-oxopropanoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: lithium aluminium tetrahydride / tetrahydrofuran / 25 h / 0 - 20 °C / Inert atmosphere

2.1: potassium carbonate / acetone / 43 h / Inert atmosphere; Reflux

2.2: 27 h / 50 °C / Inert atmosphere

3.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / chloroform / 1.5 h / 0 °C / Inert atmosphere

3.2: 18 h / 20 °C / Inert atmosphere

With lithium aluminium tetrahydride; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; chloroform; acetone;
DOI:10.1016/j.tet.2012.10.069