1,2-DISTEAROYL-SN-GLYCEROL

Base Information

• Chemical Name: 1,2-DISTEAROYL-SN-GLYCEROL
• CAS No.: 1429-59-0
• Molecular Formula: C39H76 O5
• Molecular Weight: 625.029
• Hs Code.: 2915900090
• Mol file: 1429-59-0.mol

Synonyms:Octadecanoicacid, (1R)-1-(hydroxymethyl)-1,2-ethanediyl ester (9CI); Octadecanoic acid, 1-(hydroxymethyl)-1,2-ethanediylester, (R)-; Stearin, 1,2-di-, D- (8CI); (R)-1,2-Distearin;2,3-Distearoyl-sn-glycerol; sn-2,3-Distearoylglycerol

Chemical Property of 1,2-DISTEAROYL-SN-GLYCEROL

Chemical Property:

• Vapor Pressure: 2.33E-20mmHg at 25°C
• Melting Point: 75-77°C
• Boiling Point: 662.3 °C at 760 mmHg
• Flash Point: 181.8 °C
• PSA: 72.83000
• Density: 0.923 g/cm³
• LogP: 11.95670
• Storage Temp.: -20°C Freezer, Under inert atmosphere
• Solubility.: Chloroform (Slightly), Ethyl Acetate (Slightly, Heated)

Purity/Quality:

99% ^*data from raw suppliers

1,2-Distearoyl-sn-glycerol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 1,2-Distearoyl-sn-glycerol is used in the study of the influence of platelet-derived growth factor (PDGF) on diacylglycerol phosphorylation in Swiss 3T3 cells.

Technology Process of 1,2-DISTEAROYL-SN-GLYCEROL

There total 21 articles about 1,2-DISTEAROYL-SN-GLYCEROL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

3-O-benzyl-1,2-di-O-stearoyl-rac-glycerol (76189-95-2,7145-33-7) → 1,2-distearoyl-sn-glycerol (1429-59-0,10567-21-2)

Guidance literature:

With palladium on activated charcoal; hydrogen;

DOI:10.1039/c4ob02258k

Reference yield: 94.5%

1-O-benzyl-2,3-dioctadecanoyl-sn-glycerol (158932-34-4,7145-33-7) → (2R)-1,2-bis-O-stearylglycerol (1429-59-0)

Guidance literature:

With hydrogen; palladium on activated charcoal; at 20 ℃; for 4h;

DOI:10.1016/S0040-4039(00)00638-9

Reference yield: 90.0%

Octadecanoic acid (S)-2-(3,4-dimethoxy-benzyloxy)-1-octadecanoyloxymethyl-ethyl ester (173912-48-6) → 1,2-distearoyl-sn-glycerol (1429-59-0,10567-21-2)

Guidance literature:

With 2,3-dicyano-5,6-dichloro-p-benzoquinone; In dichloromethane; water; Ambient temperature;

DOI:10.1021/jo951350k

upstream raw materials:

3-O-benzyl-1,2-dioctadecanoyl-sn-glycerol

(R)-(+)-1,2-distearoyl-3-(tert-butyldimethylsilyl)-sn-glycerol

Octadecanoic acid (S)-2-(3,4-dimethoxy-benzyloxy)-1-octadecanoyloxymethyl-ethyl ester

Octadecanoic acid (R)-2-(9H-fluoren-9-ylmethoxycarbonyloxy)-1-octadecanoyloxymethyl-ethyl ester

Downstream raw materials:

1,2-distearoyl-sn-glycero-3-phosphoethanolamine

1,2-di-O-stearoyl-sn-glycero-3-phospho-(2,4-dichlorophenol)

Octadecanoic acid (R)-2-(benzyloxy-diisopropylamino-phosphanyloxy)-1-octadecanoyloxymethyl-ethyl ester

Octadecanoic acid (R)-2-{(2-chloro-phenoxy)-[(2R,3R,4S,5R)-5-[2-oxo-4-(4-oxo-pentanoylamino)-2H-pyrimidin-1-yl]-3,4-bis-(4-oxo-pentanoyloxy)-tetrahydro-furan-2-ylmethoxy]-phosphoryloxy}-1-octadecanoyloxymethyl-ethyl ester

Refernces

• 1、 Gudmundsson, Haraldur G.,Haraldsson, Gudmundur G.,Kallio, Heikki,Kalpio, Marika,Linderborg, Kaisa M.,Magnússon, Jóhann D.,Yang, Baoru. "Synthesis and enantiospecific analysis of enantiostructured triacylglycerols containing n-3 polyunsaturated fatty acids". . . Retrieved 2020/07/08.
• 2、 Furse, Samuel,Mak, Lokhang,Tate, Edward W.,Templer, Richard H.,Ces, Oscar,Woscholski, Rüdiger,Gaffney, Piers R. J.. "Synthesis of unsaturated phosphatidylinositol 4-phosphates and the effects of substrate unsaturation on SopB phosphatase activity". supporting information. p. 2001 - 2011. Retrieved 2015/03/05.