(2R,4R)-N-((1S,2S)-1-hydroxy-1-phenylpropan-2-yl)-N,2,4-trimethyl-5-(trityloxy)pentanamide

Base Information

Chemical Name:(2R,4R)-N-((1S,2S)-1-hydroxy-1-phenylpropan-2-yl)-N,2,4-trimethyl-5-(trityloxy)pentanamide
CAS No.:1242061-18-2
Molecular Formula:C₃₆H₄₁NO₃
Molecular Weight:535.726
Hs Code.:

Synonyms:(2R,4R)-N-((1S,2S)-1-hydroxy-1-phenylpropan-2-yl)-N,2,4-trimethyl-5-(trityloxy)pentanamide

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Chemical Property of (2R,4R)-N-((1S,2S)-1-hydroxy-1-phenylpropan-2-yl)-N,2,4-trimethyl-5-(trityloxy)pentanamide

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Technology Process of (2R,4R)-N-((1S,2S)-1-hydroxy-1-phenylpropan-2-yl)-N,2,4-trimethyl-5-(trityloxy)pentanamide

There total 1 articles about (2R,4R)-N-((1S,2S)-1-hydroxy-1-phenylpropan-2-yl)-N,2,4-trimethyl-5-(trityloxy)pentanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 159213-03-3
N-[(1S,2S)-2-hydroxy-1-methyl-2-phenylethyl]-N-methylpropionamide

: (S)-3-trityloxy-2-methyl-1-iodo-propane

: 1242061-18-2
(2R,4R)-N-((1S,2S)-1-hydroxy-1-phenylpropan-2-yl)-N,2,4-trimethyl-5-(trityloxy)pentanamide

Guidance literature:: N-[(1S,2S)-2-hydroxy-1-methyl-2-phenylethyl]-N-methylpropionamide; With lithium chloride; lithium diisopropyl amide; In tetrahydrofuran; hexane; at -78 - 20 ℃; for 2.33333h; Inert atmosphere;

(S)-3-trityloxy-2-methyl-1-iodo-propane; In tetrahydrofuran; hexane; at 0 - 45 ℃; Inert atmosphere;
DOI:10.1039/c004199h

Reference yield: 91.0%

: 1242061-18-2
(2R,4R)-N-((1S,2S)-1-hydroxy-1-phenylpropan-2-yl)-N,2,4-trimethyl-5-(trityloxy)pentanamide

: 1242061-19-3
(2R,4R)-2,4-dimethyl-5-(trityloxy)pentan-1-ol

Guidance literature:: With lithium amidotrihydroborate; lithium diisopropyl amide; In tetrahydrofuran; hexane; at 0 - 20 ℃; Inert atmosphere;
DOI:10.1039/c004199h

Reference yield:

: 1242061-18-2
(2R,4R)-N-((1S,2S)-1-hydroxy-1-phenylpropan-2-yl)-N,2,4-trimethyl-5-(trityloxy)pentanamide

: C₃₀H₃₄O₃

Guidance literature:: Multi-step reaction with 3 steps

1: n-butyllithium; diisopropylamine; lithium amidotrihydroborate; hydrogenchloride / tetrahydrofuran; water / 2.33 h / -78 - 20 °C / Inert atmosphere

2: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / dimethyl sulfoxide / 2.5 h / 20 °C / Inert atmosphere

3: toluene / 100 °C

With hydrogenchloride; n-butyllithium; lithium amidotrihydroborate; diisopropylamine; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; In tetrahydrofuran; water; dimethyl sulfoxide; toluene;
DOI:10.1002/chem.201201585