2-{1-[(4S,5R)-2-(6-tert-butyl-4-ethoxy-pyridin-3-yl)-4,5-bis-(4-chloro-phenyl)-4,5-dimethyl-4,5-dihydro-imidazole-1-carbonyl]-piperidin-4-yl}-acetamide

Base Information

Chemical Name:2-{1-[(4S,5R)-2-(6-tert-butyl-4-ethoxy-pyridin-3-yl)-4,5-bis-(4-chloro-phenyl)-4,5-dimethyl-4,5-dihydro-imidazole-1-carbonyl]-piperidin-4-yl}-acetamide
CAS No.:1143522-26-2
Molecular Formula:C₃₆H₄₃Cl₂N₅O₃
Molecular Weight:664.675
Hs Code.:

Synonyms:2-{1-[(4S,5R)-2-(6-tert-butyl-4-ethoxy-pyridin-3-yl)-4,5-bis-(4-chloro-phenyl)-4,5-dimethyl-4,5-dihydro-imidazole-1-carbonyl]-piperidin-4-yl}-acetamide

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Chemical Property of 2-{1-[(4S,5R)-2-(6-tert-butyl-4-ethoxy-pyridin-3-yl)-4,5-bis-(4-chloro-phenyl)-4,5-dimethyl-4,5-dihydro-imidazole-1-carbonyl]-piperidin-4-yl}-acetamide

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Technology Process of 2-{1-[(4S,5R)-2-(6-tert-butyl-4-ethoxy-pyridin-3-yl)-4,5-bis-(4-chloro-phenyl)-4,5-dimethyl-4,5-dihydro-imidazole-1-carbonyl]-piperidin-4-yl}-acetamide

There total 13 articles about 2-{1-[(4S,5R)-2-(6-tert-butyl-4-ethoxy-pyridin-3-yl)-4,5-bis-(4-chloro-phenyl)-4,5-dimethyl-4,5-dihydro-imidazole-1-carbonyl]-piperidin-4-yl}-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 2-{1-[(4S,5R)-2-(6-tert-butyl-4-ethoxypyridin-3-yl)-4,5-bis-(4-chlorophenyl)-4,5-dimethyl-4,5-dihydroimidazole-1-carbonyl]piperidin-4-yl}acetamide (R)-camphorsulfonic acid

: 1143522-26-2
2-{1-[(4S,5R)-2-(6-tert-butyl-4-ethoxy-pyridin-3-yl)-4,5-bis-(4-chloro-phenyl)-4,5-dimethyl-4,5-dihydro-imidazole-1-carbonyl]-piperidin-4-yl}-acetamide

Guidance literature:: With sodium carbonate; In water; ethyl acetate; for 2h; Large scale;
DOI:10.1021/op300294g

Reference yield:

: 1538-75-6
2,2-dimethylpropanoic anhydride

: 1143522-26-2
2-{1-[(4S,5R)-2-(6-tert-butyl-4-ethoxy-pyridin-3-yl)-4,5-bis-(4-chloro-phenyl)-4,5-dimethyl-4,5-dihydro-imidazole-1-carbonyl]-piperidin-4-yl}-acetamide

Guidance literature:: Multi-step reaction with 10 steps

1.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.33 h / -75 - -50 °C

1.2: 0.5 h / 20 - 60 °C

2.1: potassium carbonate / N,N-dimethyl-formamide / 0.5 h / 60 °C

2.2: 60 °C

3.1: sodium hydroxide / tetrahydrofuran; ethanol / 2 h / 50 °C

4.1: benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine / 2-methyltetrahydrofuran / 0.17 h / Large scale

4.2: Large scale

5.1: pyridine / toluene / 4.5 h / Reflux; Large scale

6.1: sodium carbonate / toluene; dichloromethane; water; ethyl acetate / 1 h / 20 °C / Large scale

7.1: N-ethyl-N,N-diisopropylamine; 2,6-dimethylpyridine / dichloromethane / -7 - 0 °C / Large scale

8.1: N-ethyl-N,N-diisopropylamine / dichloromethane / Large scale

9.1: tetrahydrofuran / 20 °C / Reflux; Resolution of racemate; Large scale

10.1: sodium carbonate / water; ethyl acetate / 2 h / Large scale

With pyridine; 2,6-dimethylpyridine; sodium carbonate; potassium carbonate; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; sodium hydroxide; lithium hexamethyldisilazane; In tetrahydrofuran; 2-methyltetrahydrofuran; ethanol; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide; toluene;
DOI:10.1021/op300294g

Reference yield:

: 1415334-30-3
sodium 6-tert-butyl-4-ethoxynicotinate

: 1143522-26-2
2-{1-[(4S,5R)-2-(6-tert-butyl-4-ethoxy-pyridin-3-yl)-4,5-bis-(4-chloro-phenyl)-4,5-dimethyl-4,5-dihydro-imidazole-1-carbonyl]-piperidin-4-yl}-acetamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine / 2-methyltetrahydrofuran / 0.17 h / Large scale

1.2: Large scale

2.1: phosphorus pentoxide / toluene / Reflux; Large scale

2.2: Large scale

3.1: N-ethyl-N,N-diisopropylamine; 2,6-dimethylpyridine / dichloromethane / 1 h / 5 °C

4.1: N-ethyl-N,N-diisopropylamine / dichloromethane / Large scale

5.1: tetrahydrofuran / 20 °C / Reflux; Resolution of racemate; Large scale

6.1: sodium carbonate / water; ethyl acetate / 2 h / Large scale

With 2,6-dimethylpyridine; phosphorus pentoxide; sodium carbonate; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; 2-methyltetrahydrofuran; dichloromethane; water; ethyl acetate; toluene;
DOI:10.1021/op300294g