(S) Methyl 2-butyl-5-chloro-3-[[4-[[2-[2-(methoxycarbonyl)-1H-pyrrol-1-yl]-1-oxo-3-phenylpropyl] amino]phenyl]methyl]-3H-imidazole 4-acetate

Base Information

Chemical Name:(S) Methyl 2-butyl-5-chloro-3-[[4-[[2-[2-(methoxycarbonyl)-1H-pyrrol-1-yl]-1-oxo-3-phenylpropyl] amino]phenyl]methyl]-3H-imidazole 4-acetate
CAS No.:148549-75-1
Molecular Formula:C₃₂H₃₅ClN₄O₅
Molecular Weight:591.107
Hs Code.:

Synonyms:(S) Methyl 2-butyl-5-chloro-3-[[4-[[2-[2-(methoxycarbonyl)-1H-pyrrol-1-yl]-1-oxo-3-phenylpropyl] amino]phenyl]methyl]-3H-imidazole 4-acetate

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Chemical Property of (S) Methyl 2-butyl-5-chloro-3-[[4-[[2-[2-(methoxycarbonyl)-1H-pyrrol-1-yl]-1-oxo-3-phenylpropyl] amino]phenyl]methyl]-3H-imidazole 4-acetate

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Technology Process of (S) Methyl 2-butyl-5-chloro-3-[[4-[[2-[2-(methoxycarbonyl)-1H-pyrrol-1-yl]-1-oxo-3-phenylpropyl] amino]phenyl]methyl]-3H-imidazole 4-acetate

There total 10 articles about (S) Methyl 2-butyl-5-chloro-3-[[4-[[2-[2-(methoxycarbonyl)-1H-pyrrol-1-yl]-1-oxo-3-phenylpropyl] amino]phenyl]methyl]-3H-imidazole 4-acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 43.0%

: 114772-05-3
methyl 2-butyl-4-chloro-1-(4-aminobenzyl)-imidazole-5-acetate

: 148549-69-3
(S)-2-(methoxycarbonyl)-α-(phenylmethyl)-1H-pyrrole-1-acetic acid

: 148549-75-1
(S) Methyl 2-butyl-5-chloro-3-[[4-[[2-[2-(methoxycarbonyl)-1H-pyrrol-1-yl]-1-oxo-3-phenylpropyl] amino]phenyl]methyl]-3H-imidazole 4-acetate

Guidance literature:: With dicyclohexyl-carbodiimide; In N,N-dimethyl-formamide; for 48h; Ambient temperature;
DOI:10.1021/jm00064a007

Reference yield:

: 114799-92-7
2-Butyl-4-chloro-1-[(4-nitrophenyl)methyl]-1H-imidazole-5-methanol

: 148549-75-1
(S) Methyl 2-butyl-5-chloro-3-[[4-[[2-[2-(methoxycarbonyl)-1H-pyrrol-1-yl]-1-oxo-3-phenylpropyl] amino]phenyl]methyl]-3H-imidazole 4-acetate

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) SO₂Cl₂, 2.) n-Bu₄NBr / 1.) CHCl₃, reflux, 3 h, 2.) CHCl₃, H₂O, RT, 2 h

2: 6 N aq. HCl / 3 h / Heating

3: 6.0 g / HCl (g), CH(OMe)3 / 3 h / Heating

4: H₂ / Raney Ni / tetrahydrofuran / 23 °C / 2585.7 Torr

5: 43 percent / DCC / dimethylformamide / 48 h / Ambient temperature

With hydrogenchloride; sulfuryl dichloride; tetrabutylammomium bromide; hydrogen; dicyclohexyl-carbodiimide; trimethyl orthoformate; nickel; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1021/jm00064a007

Reference yield:

: 114771-99-2
2-Butyl-4-chloro-5-(cyanomethyl]-l-[(4-nitrophenyl)-methyl]imidazole

: 148549-75-1
(S) Methyl 2-butyl-5-chloro-3-[[4-[[2-[2-(methoxycarbonyl)-1H-pyrrol-1-yl]-1-oxo-3-phenylpropyl] amino]phenyl]methyl]-3H-imidazole 4-acetate

Guidance literature:: Multi-step reaction with 4 steps

1: 6 N aq. HCl / 3 h / Heating

2: 6.0 g / HCl (g), CH(OMe)3 / 3 h / Heating

3: H₂ / Raney Ni / tetrahydrofuran / 23 °C / 2585.7 Torr

4: 43 percent / DCC / dimethylformamide / 48 h / Ambient temperature

With hydrogenchloride; hydrogen; dicyclohexyl-carbodiimide; trimethyl orthoformate; nickel; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1021/jm00064a007