({[Benzyl-(2-{benzyl-[2-(tert-butoxycarbonyl-carboxymethyl-amino)-acetyl]-amino}-ethyl)-carbamoyl]-methyl}-tert-butoxycarbonyl-amino)-acetic acid

Base Information

• Chemical Name: ({[Benzyl-(2-{benzyl-[2-(tert-butoxycarbonyl-carboxymethyl-amino)-acetyl]-amino}-ethyl)-carbamoyl]-methyl}-tert-butoxycarbonyl-amino)-acetic acid
• CAS No.: 155788-77-5
• Molecular Formula: C₃₄H₄₆N₄O₁₀
• Molecular Weight: 670.76
• Mol file: 155788-77-5.mol

Synonyms:({[Benzyl-(2-{benzyl-[2-(tert-butoxycarbonyl-carboxymethyl-amino)-acetyl]-amino}-ethyl)-carbamoyl]-methyl}-tert-butoxycarbonyl-amino)-acetic acid

Chemical Property of ({[Benzyl-(2-{benzyl-[2-(tert-butoxycarbonyl-carboxymethyl-amino)-acetyl]-amino}-ethyl)-carbamoyl]-methyl}-tert-butoxycarbonyl-amino)-acetic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ({[Benzyl-(2-{benzyl-[2-(tert-butoxycarbonyl-carboxymethyl-amino)-acetyl]-amino}-ethyl)-carbamoyl]-methyl}-tert-butoxycarbonyl-amino)-acetic acid

There total 4 articles about ({[Benzyl-(2-{benzyl-[2-(tert-butoxycarbonyl-carboxymethyl-amino)-acetyl]-amino}-ethyl)-carbamoyl]-methyl}-tert-butoxycarbonyl-amino)-acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

N-((tert-butyloxy)carbonyl)iminodiacetic acid anhydride (56074-21-6) + N,N'-Dibenzylethylenediamine (140-28-3,87170-83-0) → ({[Benzyl-(2-{benzyl-[2-(tert-butoxycarbonyl-carboxymethyl-amino)-acetyl]-amino}-ethyl)-carbamoyl]-methyl}-tert-butoxycarbonyl-amino)-acetic acid (155788-77-5)

Guidance literature:

In tetrahydrofuran; at 50 ℃; for 24h;

DOI:10.1002/1099-0690(200106)2001:11<2165::AID-EJOC2165>3.0.CO;2-F

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) → ({[Benzyl-(2-{benzyl-[2-(tert-butoxycarbonyl-carboxymethyl-amino)-acetyl]-amino}-ethyl)-carbamoyl]-methyl}-tert-butoxycarbonyl-amino)-acetic acid (155788-77-5)

Guidance literature:

Multi-step reaction with 3 steps

1: 88 percent / aq. NaOH / dioxane / 18 h / Ambient temperature

2: dicyclohexylcarbodiimide / tetrahydrofuran / 24 h

3: tetrahydrofuran / 24 h / 50 °C

With sodium hydroxide; dicyclohexyl-carbodiimide; In tetrahydrofuran; 1,4-dioxane;

DOI:10.1016/0040-4020(96)00529-7

Reference yield:

N-((tert-butyloxy)carbonyl)iminodiacetic acid (56074-20-5) → ({[Benzyl-(2-{benzyl-[2-(tert-butoxycarbonyl-carboxymethyl-amino)-acetyl]-amino}-ethyl)-carbamoyl]-methyl}-tert-butoxycarbonyl-amino)-acetic acid (155788-77-5)

Guidance literature:

Multi-step reaction with 2 steps

1: dicyclohexylcarbodiimide / tetrahydrofuran / 24 h

2: tetrahydrofuran / 24 h / 50 °C

With dicyclohexyl-carbodiimide; In tetrahydrofuran;

DOI:10.1016/0040-4020(96)00529-7

upstream raw materials:

N-((tert-butyloxy)carbonyl)iminodiacetic acid anhydride

N,N'-Dibenzylethylenediamine

N-((tert-butyloxy)carbonyl)iminodiacetic acid

di-tert-butyl dicarbonate

Downstream raw materials:

4,7,13,16-Tetrabenzyl-3,8,12,17-tetraoxo-1,4,7,10,13,16-hexaaza-cyclooctadecane-1,10-dicarboxylic acid di-tert-butyl ester

1,7,10,16-tetrakis(phenylmethyl)-1,4,7,10,13,16-hexaazacyclooctadecane-2,6,11,15-tetrone

(11,14-Dibenzyl-17-benzyloxycarbonylmethyl-10,15-dioxo-8,11,14,17,23,24-hexaaza-tricyclo[17.3.1.1^2,6]tetracosa-1⁽²³⁾,2,4,6⁽²⁴⁾,19,21-hexaen-8-yl)-acetic acid benzyl ester

({[Benzyl-(2-{benzyl-[2-(benzyloxycarbonylmethyl-amino)-acetyl]-amino}-ethyl)-carbamoyl]-methyl}-amino)-acetic acid benzyl ester