3-hydroxy-4-{[4-(propan-2-yl)phenyl]carbonyl}-5-[4-(trifluoromethoxy)phenyl]-1-{6-[2-(trimethylsilyl)ethynyl]pyridazin-3-yl}-2,5-dihydro-1H-pyrrol-2-one

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Chemical Name:3-hydroxy-4-{[4-(propan-2-yl)phenyl]carbonyl}-5-[4-(trifluoromethoxy)phenyl]-1-{6-[2-(trimethylsilyl)ethynyl]pyridazin-3-yl}-2,5-dihydro-1H-pyrrol-2-one
CAS No.:1384878-22-1
Molecular Formula:C₃₀H₂₈F₃N₃O₄Si
Molecular Weight:579.651
Hs Code.:

3-hydroxy-4-{[4-(propan-2-yl)phenyl]carbonyl}-5-[4-(trifluoromethoxy)phenyl]-1-{6-[2-(trimethylsilyl)ethynyl]pyridazin-3-yl}-2,5-dihydro-1H-pyrrol-2-one

Synonyms:3-hydroxy-4-{[4-(propan-2-yl)phenyl]carbonyl}-5-[4-(trifluoromethoxy)phenyl]-1-{6-[2-(trimethylsilyl)ethynyl]pyridazin-3-yl}-2,5-dihydro-1H-pyrrol-2-one

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Chemical Property of 3-hydroxy-4-{[4-(propan-2-yl)phenyl]carbonyl}-5-[4-(trifluoromethoxy)phenyl]-1-{6-[2-(trimethylsilyl)ethynyl]pyridazin-3-yl}-2,5-dihydro-1H-pyrrol-2-one

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Technology Process of 3-hydroxy-4-{[4-(propan-2-yl)phenyl]carbonyl}-5-[4-(trifluoromethoxy)phenyl]-1-{6-[2-(trimethylsilyl)ethynyl]pyridazin-3-yl}-2,5-dihydro-1H-pyrrol-2-one

There total 2 articles about 3-hydroxy-4-{[4-(propan-2-yl)phenyl]carbonyl}-5-[4-(trifluoromethoxy)phenyl]-1-{6-[2-(trimethylsilyl)ethynyl]pyridazin-3-yl}-2,5-dihydro-1H-pyrrol-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 852814-99-4
ethyl 4-[4-(1-methylethyl)phenyl]-2,4-dioxobutanoate

: 1384878-22-1
3-hydroxy-4-{[4-(propan-2-yl)phenyl]carbonyl}-5-[4-(trifluoromethoxy)phenyl]-1-{6-[2-(trimethylsilyl)ethynyl]pyridazin-3-yl}-2,5-dihydro-1H-pyrrol-2-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: acetic acid / ethanol / 0.25 h / 20 °C

1.2: 16 h / Reflux

2.1: triethylamine / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; copper(l) iodide / tetrahydrofuran / 16 h / 20 °C / Inert atmosphere

With triethylamine; copper(l) iodide; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; acetic acid; In tetrahydrofuran; ethanol;

Reference yield:

: 645-13-6
4-isopropylacetophenone

: 1384878-22-1
3-hydroxy-4-{[4-(propan-2-yl)phenyl]carbonyl}-5-[4-(trifluoromethoxy)phenyl]-1-{6-[2-(trimethylsilyl)ethynyl]pyridazin-3-yl}-2,5-dihydro-1H-pyrrol-2-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: ethanol; sodium / 0.5 h / 20 °C

1.2: 16 h / Reflux

2.1: acetic acid / ethanol / 0.25 h / 20 °C

2.2: 16 h / Reflux

3.1: triethylamine / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; copper(l) iodide / tetrahydrofuran / 16 h / 20 °C / Inert atmosphere

With ethanol; sodium; triethylamine; copper(l) iodide; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; acetic acid; In tetrahydrofuran; ethanol;