(E)-1-(4-isopropyl-2,3-dimethoxyphenyl)-8-methoxy-5,5,6-trimethyloct-6-en-1-yn-3-ol

Base Information

Chemical Name:(E)-1-(4-isopropyl-2,3-dimethoxyphenyl)-8-methoxy-5,5,6-trimethyloct-6-en-1-yn-3-ol
CAS No.:1445569-50-5
Molecular Formula:C₂₃H₃₄O₄
Molecular Weight:374.521
Hs Code.:

Synonyms:(E)-1-(4-isopropyl-2,3-dimethoxyphenyl)-8-methoxy-5,5,6-trimethyloct-6-en-1-yn-3-ol

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Chemical Property of (E)-1-(4-isopropyl-2,3-dimethoxyphenyl)-8-methoxy-5,5,6-trimethyloct-6-en-1-yn-3-ol

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Technology Process of (E)-1-(4-isopropyl-2,3-dimethoxyphenyl)-8-methoxy-5,5,6-trimethyloct-6-en-1-yn-3-ol

There total 11 articles about (E)-1-(4-isopropyl-2,3-dimethoxyphenyl)-8-methoxy-5,5,6-trimethyloct-6-en-1-yn-3-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 1445569-44-7
1-ethynyl-4-isopropyl-2,3-dimethoxybenzene

: 1445569-32-3
(4E)-6-methoxy-3,3,4-trimethyl-hex-4-enal

: 1445569-50-5
(E)-1-(4-isopropyl-2,3-dimethoxyphenyl)-8-methoxy-5,5,6-trimethyloct-6-en-1-yn-3-ol

Guidance literature:: 1-ethynyl-4-isopropyl-2,3-dimethoxybenzene; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 0.5h; Inert atmosphere;

(4E)-6-methoxy-3,3,4-trimethyl-hex-4-enal; In tetrahydrofuran; hexane; at -78 ℃; for 4h; Inert atmosphere;
DOI:10.1021/ol401543b

Reference yield:

: 1445569-37-8
C₁₁H₁₅IO₂

: 1445569-50-5
(E)-1-(4-isopropyl-2,3-dimethoxyphenyl)-8-methoxy-5,5,6-trimethyloct-6-en-1-yn-3-ol

Guidance literature:: Multi-step reaction with 3 steps

1.1: palladium dichloride; triphenylphosphine; copper(l) iodide; diisopropylamine / tetrahydrofuran / 0.5 h / 20 °C / Inert atmosphere

1.2: 12 h / Reflux; Inert atmosphere

2.1: potassium carbonate / methanol / 1 h / 20 °C / Inert atmosphere

3.1: n-butyllithium / tetrahydrofuran; hexane / 0.5 h / -78 °C / Inert atmosphere

3.2: 4 h / -78 °C / Inert atmosphere

With copper(l) iodide; n-butyllithium; potassium carbonate; diisopropylamine; triphenylphosphine; palladium dichloride; In tetrahydrofuran; methanol; hexane; 1.2: |Sonogashira Cross-Coupling;
DOI:10.1021/ol401543b

Reference yield:

: 1445569-41-4
(4-isopropyl-2,3-dimethoxyphenyl)ethynyltrimethylsilane

: 1445569-50-5
(E)-1-(4-isopropyl-2,3-dimethoxyphenyl)-8-methoxy-5,5,6-trimethyloct-6-en-1-yn-3-ol

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium carbonate / methanol / 1 h / 20 °C / Inert atmosphere

2.1: n-butyllithium / tetrahydrofuran; hexane / 0.5 h / -78 °C / Inert atmosphere

2.2: 4 h / -78 °C / Inert atmosphere

With n-butyllithium; potassium carbonate; In tetrahydrofuran; methanol; hexane;
DOI:10.1021/ol401543b