tert-butyl 4-[2,4-dioxo-6-phenyl-1-{[3-(propoxymethyl)-1,2,4-oxadiazol-5-yl]methyl}-1,4-dihydrothieno[3,2-d]pyrimidin-3(2H)-yl]piperidine-1-carboxylate

Base Information

Chemical Name:tert-butyl 4-[2,4-dioxo-6-phenyl-1-{[3-(propoxymethyl)-1,2,4-oxadiazol-5-yl]methyl}-1,4-dihydrothieno[3,2-d]pyrimidin-3(2H)-yl]piperidine-1-carboxylate
CAS No.:1312600-52-4
Molecular Formula:C₂₉H₃₅N₅O₆S
Molecular Weight:581.693
Hs Code.:

tert-butyl 4-[2,4-dioxo-6-phenyl-1-{[3-(propoxymethyl)-1,2,4-oxadiazol-5-yl]methyl}-1,4-dihydrothieno[3,2-d]pyrimidin-3(2H)-yl]piperidine-1-carboxylate

Synonyms:tert-butyl 4-[2,4-dioxo-6-phenyl-1-{[3-(propoxymethyl)-1,2,4-oxadiazol-5-yl]methyl}-1,4-dihydrothieno[3,2-d]pyrimidin-3(2H)-yl]piperidine-1-carboxylate

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Chemical Property of tert-butyl 4-[2,4-dioxo-6-phenyl-1-{[3-(propoxymethyl)-1,2,4-oxadiazol-5-yl]methyl}-1,4-dihydrothieno[3,2-d]pyrimidin-3(2H)-yl]piperidine-1-carboxylate

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Technology Process of tert-butyl 4-[2,4-dioxo-6-phenyl-1-{[3-(propoxymethyl)-1,2,4-oxadiazol-5-yl]methyl}-1,4-dihydrothieno[3,2-d]pyrimidin-3(2H)-yl]piperidine-1-carboxylate

There total 5 articles about tert-butyl 4-[2,4-dioxo-6-phenyl-1-{[3-(propoxymethyl)-1,2,4-oxadiazol-5-yl]methyl}-1,4-dihydrothieno[3,2-d]pyrimidin-3(2H)-yl]piperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1312601-21-0
[3-(propoxymethyl)-1,2,4-oxadiazol-5-yl]methanol

: 1312600-36-4
tert-butyl 4-(2,4-dioxo-6-phenyl-1,4-dihydrothieno[3,2-d]pyrimidin-3(2H)-yl)piperidine-1-carboxylate

: 1312600-52-4
tert-butyl 4-[2,4-dioxo-6-phenyl-1-{[3-(propoxymethyl)-1,2,4-oxadiazol-5-yl]methyl}-1,4-dihydrothieno[3,2-d]pyrimidin-3(2H)-yl]piperidine-1-carboxylate

Guidance literature:: [3-(propoxymethyl)-1,2,4-oxadiazol-5-yl]methanol; With carbon tetrabromide; triphenylphosphine; In dichloromethane; at 20 ℃; for 0.25h;

tert-butyl 4-(2,4-dioxo-6-phenyl-1,4-dihydrothieno[3,2-d]pyrimidin-3(2H)-yl)piperidine-1-carboxylate; With potassium carbonate; In dichloromethane; N,N-dimethyl-formamide; at 65 ℃; for 3h;

Reference yield:

: 87120-72-7
1-(tert-butoxycarbonyl)-4-aminopiperidine

: 1312600-52-4
tert-butyl 4-[2,4-dioxo-6-phenyl-1-{[3-(propoxymethyl)-1,2,4-oxadiazol-5-yl]methyl}-1,4-dihydrothieno[3,2-d]pyrimidin-3(2H)-yl]piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: tetrahydrofuran / 17 h / 0 - 20 °C / Inert atmosphere

1.2: 3 h / 0 - 20 °C / Inert atmosphere

2.1: sodium methylate / methanol / 72 h / 20 °C / Reflux

3.1: carbon tetrabromide; triphenylphosphine / dichloromethane / 0.25 h / 20 °C

3.2: 3 h / 65 °C

With carbon tetrabromide; sodium methylate; triphenylphosphine; In tetrahydrofuran; methanol; dichloromethane;

Reference yield:

: 66502-25-8
propoxyacetonitrile

: 1312600-52-4
tert-butyl 4-[2,4-dioxo-6-phenyl-1-{[3-(propoxymethyl)-1,2,4-oxadiazol-5-yl]methyl}-1,4-dihydrothieno[3,2-d]pyrimidin-3(2H)-yl]piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: hydroxylamine / water / 2 h / 100 °C

2.1: calcium hydride / tetrahydrofuran / 0.17 h / Inert atmosphere; Molecular sieve 4?

2.2: 3 h / Inert atmosphere; Reflux

3.1: sodium tetrahydroborate; methanol / 0.25 h / -10 °C

4.1: carbon tetrabromide; triphenylphosphine / dichloromethane / 0.25 h / 20 °C

4.2: 3 h / 65 °C

With methanol; sodium tetrahydroborate; calcium hydride; carbon tetrabromide; hydroxylamine; triphenylphosphine; In tetrahydrofuran; dichloromethane; water;