2-Bromo-5-[dimethyl-(1,1,2-trimethyl-propyl)-silanyloxy]-3-methoxy-6-{(R)-2-methoxycarbonyl-2-[4-(4-nitro-phenyl)-thiazol-2-ylamino]-ethylsulfanylmethyl}-benzoic acid methyl ester

Base Information

Chemical Name:2-Bromo-5-[dimethyl-(1,1,2-trimethyl-propyl)-silanyloxy]-3-methoxy-6-{(R)-2-methoxycarbonyl-2-[4-(4-nitro-phenyl)-thiazol-2-ylamino]-ethylsulfanylmethyl}-benzoic acid methyl ester
CAS No.:329015-89-6
Molecular Formula:C₃₁H₄₀BrN₃O₈S₂Si
Molecular Weight:754.795
Hs Code.:

2-Bromo-5-[dimethyl-(1,1,2-trimethyl-propyl)-silanyloxy]-3-methoxy-6-{(R)-2-methoxycarbonyl-2-[4-(4-nitro-phenyl)-thiazol-2-ylamino]-ethylsulfanylmethyl}-benzoic acid methyl ester

Synonyms:2-Bromo-5-[dimethyl-(1,1,2-trimethyl-propyl)-silanyloxy]-3-methoxy-6-{(R)-2-methoxycarbonyl-2-[4-(4-nitro-phenyl)-thiazol-2-ylamino]-ethylsulfanylmethyl}-benzoic acid methyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-Bromo-5-[dimethyl-(1,1,2-trimethyl-propyl)-silanyloxy]-3-methoxy-6-{(R)-2-methoxycarbonyl-2-[4-(4-nitro-phenyl)-thiazol-2-ylamino]-ethylsulfanylmethyl}-benzoic acid methyl ester

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 2-Bromo-5-[dimethyl-(1,1,2-trimethyl-propyl)-silanyloxy]-3-methoxy-6-{(R)-2-methoxycarbonyl-2-[4-(4-nitro-phenyl)-thiazol-2-ylamino]-ethylsulfanylmethyl}-benzoic acid methyl ester

There total 4 articles about 2-Bromo-5-[dimethyl-(1,1,2-trimethyl-propyl)-silanyloxy]-3-methoxy-6-{(R)-2-methoxycarbonyl-2-[4-(4-nitro-phenyl)-thiazol-2-ylamino]-ethylsulfanylmethyl}-benzoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 329015-88-5
(R)-3-Mercapto-2-[4-(4-nitro-phenyl)-thiazol-2-ylamino]-propionic acid methyl ester

: 2-bromo-5-dimethylthexylsilyloxy-6-formyl-3-methoxybenzoic acid methyl ester

: 329015-89-6
2-Bromo-5-[dimethyl-(1,1,2-trimethyl-propyl)-silanyloxy]-3-methoxy-6-{(R)-2-methoxycarbonyl-2-[4-(4-nitro-phenyl)-thiazol-2-ylamino]-ethylsulfanylmethyl}-benzoic acid methyl ester

Guidance literature:: With triethylsilane; trifluoroacetic acid; In dichloromethane; at 0 ℃; for 18h;
DOI:10.1021/jm0010623

Reference yield:

: 99-81-0
4-Nitrophenacyl bromide

: 329015-89-6
2-Bromo-5-[dimethyl-(1,1,2-trimethyl-propyl)-silanyloxy]-3-methoxy-6-{(R)-2-methoxycarbonyl-2-[4-(4-nitro-phenyl)-thiazol-2-ylamino]-ethylsulfanylmethyl}-benzoic acid methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 99 percent / acetonitrile / 3 h / 45 °C

2: Et₃N / ethanol / 16 h / 50 °C

3: Et₃SiH; TFA / CH₂Cl₂ / 2 h / 20 °C

4: TFA; Et₃SiH / CH₂Cl₂ / 18 h / 0 °C

With triethylsilane; triethylamine; trifluoroacetic acid; In ethanol; dichloromethane; acetonitrile;
DOI:10.1021/jm0010623

Reference yield:

: 6097-21-8
2-(4-nitrophenyl)-2-oxoethyl thiocyanate

: 329015-89-6
2-Bromo-5-[dimethyl-(1,1,2-trimethyl-propyl)-silanyloxy]-3-methoxy-6-{(R)-2-methoxycarbonyl-2-[4-(4-nitro-phenyl)-thiazol-2-ylamino]-ethylsulfanylmethyl}-benzoic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: Et₃N / ethanol / 16 h / 50 °C

2: Et₃SiH; TFA / CH₂Cl₂ / 2 h / 20 °C

3: TFA; Et₃SiH / CH₂Cl₂ / 18 h / 0 °C

With triethylsilane; triethylamine; trifluoroacetic acid; In ethanol; dichloromethane;
DOI:10.1021/jm0010623