N-α-(tert-butoxycarbonyl)-N,N-di(tert-butoxycarbonyl)-O-(tert-butyl(dimethyl)silyl)-L-tyrosinamide

Base Information

Chemical Name:N-α-(tert-butoxycarbonyl)-N,N-di(tert-butoxycarbonyl)-O-(tert-butyl(dimethyl)silyl)-L-tyrosinamide
CAS No.:503157-94-6
Molecular Formula:C₃₀H₅₀N₂O₈Si
Molecular Weight:594.821
Hs Code.:

Synonyms:N-α-(tert-butoxycarbonyl)-N,N-di(tert-butoxycarbonyl)-O-(tert-butyl(dimethyl)silyl)-L-tyrosinamide

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Chemical Property of N-α-(tert-butoxycarbonyl)-N,N-di(tert-butoxycarbonyl)-O-(tert-butyl(dimethyl)silyl)-L-tyrosinamide

Chemical Property:

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Technology Process of N-α-(tert-butoxycarbonyl)-N,N-di(tert-butoxycarbonyl)-O-(tert-butyl(dimethyl)silyl)-L-tyrosinamide

There total 3 articles about N-α-(tert-butoxycarbonyl)-N,N-di(tert-butoxycarbonyl)-O-(tert-butyl(dimethyl)silyl)-L-tyrosinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 24424-99-5
di-tert-butyl dicarbonate

: 292163-99-6
tert-butyl (S)-(1-amino-3-(4-((tert-butyldimethylsilyl)oxy)phenyl)-1-oxopropan-2-yl)carbamate

: 503157-94-6
N-α-(tert-butoxycarbonyl)-N,N-di(tert-butoxycarbonyl)-O-(tert-butyl(dimethyl)silyl)-L-tyrosinamide

Guidance literature:: With dmap; N-ethyl-N,N-diisopropylamine; In dichloromethane;
DOI:10.1021/jm021016y

Reference yield:

: 4326-36-7
(S)-N-(tert-butoxycarbonyl)tyrosine methyl ester

: 503157-94-6
N-α-(tert-butoxycarbonyl)-N,N-di(tert-butoxycarbonyl)-O-(tert-butyl(dimethyl)silyl)-L-tyrosinamide

Guidance literature:: Multi-step reaction with 3 steps

1: 90 percent / NH₃ / methanol / 60 h / 5 °C

2: 70 percent / imidazole; pyridine / 4 h

3: 85 percent / (iPr)2NEt; DMAP / CH₂Cl₂

With pyridine; 1H-imidazole; dmap; ammonia; N-ethyl-N,N-diisopropylamine; In methanol; dichloromethane;
DOI:10.1021/jm021016y

Reference yield:

: 83351-75-1
tert-butyl (S)-(1-amino-3-(4-hydroxyphenyl)-1-oxopropan-2-yl)carbamate

: 503157-94-6
N-α-(tert-butoxycarbonyl)-N,N-di(tert-butoxycarbonyl)-O-(tert-butyl(dimethyl)silyl)-L-tyrosinamide

Guidance literature:: Multi-step reaction with 2 steps

1: 70 percent / imidazole; pyridine / 4 h

2: 85 percent / (iPr)2NEt; DMAP / CH₂Cl₂

With pyridine; 1H-imidazole; dmap; N-ethyl-N,N-diisopropylamine; In dichloromethane;
DOI:10.1021/jm021016y