(+/-)-(6aα,8β,9aβ)-8-<2,4-dinitrophenyl)amino>hexahydro-2,2,4,4-tetrakis(1-methylethyl)cyclopenta-1,3,5,2,4-trioxadisilocin-9-one

Base Information

• Chemical Name: (+/-)-(6aα,8β,9aβ)-8-<2,4-dinitrophenyl)amino>hexahydro-2,2,4,4-tetrakis(1-methylethyl)cyclopenta-1,3,5,2,4-trioxadisilocin-9-one
• CAS No.: 110880-87-0
• Molecular Formula: C₂₄H₃₉N₃O₈Si₂
• Molecular Weight: 553.76
• Mol file: 110880-87-0.mol

Synonyms:(+/-)-(6aα,8β,9aβ)-8-<2,4-dinitrophenyl)amino>hexahydro-2,2,4,4-tetrakis(1-methylethyl)cyclopenta-1,3,5,2,4-trioxadisilocin-9-one

Chemical Property of (+/-)-(6aα,8β,9aβ)-8-<2,4-dinitrophenyl)amino>hexahydro-2,2,4,4-tetrakis(1-methylethyl)cyclopenta-1,3,5,2,4-trioxadisilocin-9-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (+/-)-(6aα,8β,9aβ)-8-<2,4-dinitrophenyl)amino>hexahydro-2,2,4,4-tetrakis(1-methylethyl)cyclopenta-1,3,5,2,4-trioxadisilocin-9-one

There total 1 articles about (+/-)-(6aα,8β,9aβ)-8-<2,4-dinitrophenyl)amino>hexahydro-2,2,4,4-tetrakis(1-methylethyl)cyclopenta-1,3,5,2,4-trioxadisilocin-9-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 17.0%

(1RS,8RS,10RS,11SR)-10-(2,4-dinitroanilino)-3,3,5,5-tetraisopropyl-2,4,6-trioxa-3,5-disilabicyclo<6.3.0>undecan-11-ol (110864-89-6) → (+/-)-(6aα,8β,9aβ)-8-<2,4-dinitrophenyl)amino>hexahydro-2,2,4,4-tetrakis(1-methylethyl)cyclopenta-1,3,5,2,4-trioxadisilocin-9-one (110880-87-0)

Guidance literature:

With phosphoric acid; oxalic acid; ethyl acetate; dicyclohexyl-carbodiimide; 1.) DMSO, RT, 3.5 h, 2.) methanol, RT, 5 min;

DOI:10.1021/jm00163a030

Reference yield: 25.0%

(+/-)-(6aα,8β,9aβ)-8-<2,4-dinitrophenyl)amino>hexahydro-2,2,4,4-tetrakis(1-methylethyl)cyclopenta-1,3,5,2,4-trioxadisilocin-9-one (110880-87-0) → (+/-)-(6aα,8β,9aβ)-9,9-difluorohexahydro-8-<2,4-dinitrophenyl)amino>-2,2,4,4-tetrakis(1-methylethyl)cyclopenta-1,3,5,2,4-trioxadisilocin (123169-16-4)

Guidance literature:

With diethylamino-sulfur trifluoride; In dichloromethane; at 5 ℃; for 1h;

DOI:10.1021/jm00163a030

Reference yield:

(+/-)-(6aα,8β,9aβ)-8-<2,4-dinitrophenyl)amino>hexahydro-2,2,4,4-tetrakis(1-methylethyl)cyclopenta-1,3,5,2,4-trioxadisilocin-9-one (110880-87-0) → (+/-)-(1α,2β,4α)-4-<(2,4-dinitrophenyl)amino>-3,3-difluoro-2-hyrroxycyclopentanemethanol (110864-99-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 25 percent / (diethylamino)sulfur trifluoride / CH₂Cl₂ / 1 h / 5 °C

2: 25 percent / tetrabutylammonium fluoride / tetrahydrofuran / 0.5 h

With diethylamino-sulfur trifluoride; tetrabutyl ammonium fluoride; In tetrahydrofuran; dichloromethane;

DOI:10.1021/jm00163a030

upstream raw materials:

(1RS,8RS,10RS,11SR)-10-(2,4-dinitroanilino)-3,3,5,5-tetraisopropyl-2,4,6-trioxa-3,5-disilabicyclo<6.3.0>undecan-11-ol

Downstream raw materials:

(+/-)-(6aα,8β,9aβ)-9,9-difluorohexahydro-8-<2,4-dinitrophenyl)amino>-2,2,4,4-tetrakis(1-methylethyl)cyclopenta-1,3,5,2,4-trioxadisilocin

(+/-)-(1α,2β,4α)-4-amino-3,3-difluoro-2-hydroxycyclopentanemethanol hydrochloride salt

(+/-)-(1α,2β,4α)-4-<(2,4-dinitrophenyl)amino>-3,3-difluoro-2-hyrroxycyclopentanemethanol