2-fluoro-4-((5-methoxythiazolo[5,4-b]pyridin-2-yl)ethynyl)-N-methylaniline

Base Information

Chemical Name:2-fluoro-4-((5-methoxythiazolo[5,4-b]pyridin-2-yl)ethynyl)-N-methylaniline
CAS No.:1246091-95-1
Molecular Formula:C₁₆H₁₂FN₃OS
Molecular Weight:313.355
Hs Code.:

Synonyms:2-fluoro-4-((5-methoxythiazolo[5,4-b]pyridin-2-yl)ethynyl)-N-methylaniline

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Chemical Property of 2-fluoro-4-((5-methoxythiazolo[5,4-b]pyridin-2-yl)ethynyl)-N-methylaniline

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Technology Process of 2-fluoro-4-((5-methoxythiazolo[5,4-b]pyridin-2-yl)ethynyl)-N-methylaniline

There total 4 articles about 2-fluoro-4-((5-methoxythiazolo[5,4-b]pyridin-2-yl)ethynyl)-N-methylaniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 31.0%

: 1246093-94-6
4-ethynyl-2-fluoro-N-methylaniline

: 1246093-96-8
2-iodo-5-snethoxythiazolo[5,4-b]pyridine

: 96042-30-7
4-(dicyanomethylene)-2-methyl-6-(p-dimethylaminostyryl)-4H-pyran

: 1246091-95-1
2-fluoro-4-((5-methoxythiazolo[5,4-b]pyridin-2-yl)ethynyl)-N-methylaniline

Guidance literature:: With CuI; triethanolamine; [Pd(PPh₃)4]; In quinoclamine;

Reference yield:

: 367-24-8
4-bromo-2-fluoroaniline

: 1246091-95-1
2-fluoro-4-((5-methoxythiazolo[5,4-b]pyridin-2-yl)ethynyl)-N-methylaniline

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium methylate / methanol / 2 h / Reflux

1.2: 1 h / 0 °C / Reflux

2.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; copper(l) iodide; diethylamine / N,N-dimethyl-formamide / 0.25 h / 100 °C / Microwave irradiation

3.1: methanol; potassium carbonate / 0.5 h / 20 °C / Microwave irradiation

4.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; copper(l) iodide; triethylamine / acetonitrile / 0.08 h / 100 °C / Microwave irradiation

With methanol; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium methylate; potassium carbonate; diethylamine; triethylamine; In methanol; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 213190-12-6
4-bromo-2-fluoro-N-methylaniline

: 1246091-95-1
2-fluoro-4-((5-methoxythiazolo[5,4-b]pyridin-2-yl)ethynyl)-N-methylaniline

Guidance literature:: Multi-step reaction with 3 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; copper(l) iodide; diethylamine / N,N-dimethyl-formamide / 0.25 h / 100 °C / Microwave irradiation

2: methanol; potassium carbonate / 0.5 h / 20 °C / Microwave irradiation

3: tetrakis(triphenylphosphine) palladium⁽⁰⁾; copper(l) iodide; triethylamine / acetonitrile / 0.08 h / 100 °C / Microwave irradiation

With methanol; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; diethylamine; triethylamine; In N,N-dimethyl-formamide; acetonitrile;