(E)-(7R,9S,10R)-3-[9-(tert-butyldiphenylsilanyloxy)-4-hydroxy-10-methyl-5-oxo-7,8,9,10,11,14-hexahydro-5H-6-oxabenzocyclododecen-7-yl]propionitrile

Base Information

Chemical Name:(E)-(7R,9S,10R)-3-[9-(tert-butyldiphenylsilanyloxy)-4-hydroxy-10-methyl-5-oxo-7,8,9,10,11,14-hexahydro-5H-6-oxabenzocyclododecen-7-yl]propionitrile
CAS No.:642486-86-0
Molecular Formula:C₃₅H₄₁NO₄Si
Molecular Weight:567.8
Hs Code.:

(E)-(7R,9S,10R)-3-[9-(tert-butyldiphenylsilanyloxy)-4-hydroxy-10-methyl-5-oxo-7,8,9,10,11,14-hexahydro-5H-6-oxabenzocyclododecen-7-yl]propionitrile

Synonyms:(E)-(7R,9S,10R)-3-[9-(tert-butyldiphenylsilanyloxy)-4-hydroxy-10-methyl-5-oxo-7,8,9,10,11,14-hexahydro-5H-6-oxabenzocyclododecen-7-yl]propionitrile

Suppliers and Price of (E)-(7R,9S,10R)-3-[9-(tert-butyldiphenylsilanyloxy)-4-hydroxy-10-methyl-5-oxo-7,8,9,10,11,14-hexahydro-5H-6-oxabenzocyclododecen-7-yl]propionitrile

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (E)-(7R,9S,10R)-3-[9-(tert-butyldiphenylsilanyloxy)-4-hydroxy-10-methyl-5-oxo-7,8,9,10,11,14-hexahydro-5H-6-oxabenzocyclododecen-7-yl]propionitrile

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (E)-(7R,9S,10R)-3-[9-(tert-butyldiphenylsilanyloxy)-4-hydroxy-10-methyl-5-oxo-7,8,9,10,11,14-hexahydro-5H-6-oxabenzocyclododecen-7-yl]propionitrile

There total 6 articles about (E)-(7R,9S,10R)-3-[9-(tert-butyldiphenylsilanyloxy)-4-hydroxy-10-methyl-5-oxo-7,8,9,10,11,14-hexahydro-5H-6-oxabenzocyclododecen-7-yl]propionitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

: 58479-61-1
tert-butylchlorodiphenylsilane

: 642486-84-8
(E)-(7R,9S,10R)-3-(4,9-dihydroxy-10-methyl-5-oxo-7,8,9,10,11,14-hexahydro-5H-6-oxabenzocyclododecen-7-yl)propionitrile

: 642486-86-0
(E)-(7R,9S,10R)-3-[9-(tert-butyldiphenylsilanyloxy)-4-hydroxy-10-methyl-5-oxo-7,8,9,10,11,14-hexahydro-5H-6-oxabenzocyclododecen-7-yl]propionitrile

Guidance literature:: With 1H-imidazole; dmap; In N,N-dimethyl-formamide; at 100 ℃; for 24h;
DOI:10.1021/jo0301550

Reference yield:

: (7S,9S,10R)-3-(4,9-dihydroxy-10-methyl-5-oxo-7,8,9,10,11,14-hexahydro-5H-6-oxabenzocyclododecen-7-yl)acrylonitrile

: 642486-86-0
(E)-(7R,9S,10R)-3-[9-(tert-butyldiphenylsilanyloxy)-4-hydroxy-10-methyl-5-oxo-7,8,9,10,11,14-hexahydro-5H-6-oxabenzocyclododecen-7-yl]propionitrile

Guidance literature:: Multi-step reaction with 2 steps

1: [Ph₃PCuH]6 / benzene / 0 - 20 °C

2: 54 percent / imidazole; DMAP / dimethylformamide / 24 h / 100 °C

With 1H-imidazole; dmap; [Ph₃PCuH]6; In N,N-dimethyl-formamide; benzene;
DOI:10.1021/jo0301550

Reference yield:

: (1S,3S,4R)-2-allyl-6-hydroxybenzoic acid 1-(2-cyanovinyl)-3-hydroxy-4-methylhept-6-enyl ester

: 642486-86-0
(E)-(7R,9S,10R)-3-[9-(tert-butyldiphenylsilanyloxy)-4-hydroxy-10-methyl-5-oxo-7,8,9,10,11,14-hexahydro-5H-6-oxabenzocyclododecen-7-yl]propionitrile

Guidance literature:: Multi-step reaction with 3 steps

1: 33 percent / Cl₂(PCy₃)2Ru=CHPh / CH₂Cl₂ / 24 h / Heating

2: [Ph₃PCuH]6 / benzene / 0 - 20 °C

3: 54 percent / imidazole; DMAP / dimethylformamide / 24 h / 100 °C

With 1H-imidazole; dmap; Grubbs catalyst first generation; [Ph₃PCuH]6; In dichloromethane; N,N-dimethyl-formamide; benzene;
DOI:10.1021/jo0301550