N-{5-[2,4-bis-octyloxy-5-(4-octyloxy-pyridin-3-ylcarbamoyl)-phenylcarbamoyl]-2,4-bis-octyloxy-phenyl}-N',N'-diethyl-malonamide

Base Information

Chemical Name:N-{5-[2,4-bis-octyloxy-5-(4-octyloxy-pyridin-3-ylcarbamoyl)-phenylcarbamoyl]-2,4-bis-octyloxy-phenyl}-N',N'-diethyl-malonamide
CAS No.:916983-52-3
Molecular Formula:C₆₆H₁₀₇N₅O₉
Molecular Weight:1114.6
Hs Code.:

<i>N</i>-{5-[2,4-bis-octyloxy-5-(4-octyloxy-pyridin-3-ylcarbamoyl)-phenylcarbamoyl]-2,4-bis-octyloxy-phenyl}-<i>N</i>',<i>N</i>'-diethyl-malonamide

Synonyms:N-{5-[2,4-bis-octyloxy-5-(4-octyloxy-pyridin-3-ylcarbamoyl)-phenylcarbamoyl]-2,4-bis-octyloxy-phenyl}-N',N'-diethyl-malonamide

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Chemical Property of N-{5-[2,4-bis-octyloxy-5-(4-octyloxy-pyridin-3-ylcarbamoyl)-phenylcarbamoyl]-2,4-bis-octyloxy-phenyl}-N',N'-diethyl-malonamide

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Technology Process of N-{5-[2,4-bis-octyloxy-5-(4-octyloxy-pyridin-3-ylcarbamoyl)-phenylcarbamoyl]-2,4-bis-octyloxy-phenyl}-N',N'-diethyl-malonamide

There total 10 articles about N-{5-[2,4-bis-octyloxy-5-(4-octyloxy-pyridin-3-ylcarbamoyl)-phenylcarbamoyl]-2,4-bis-octyloxy-phenyl}-N',N'-diethyl-malonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 916983-43-2
4-octyloxy-pyridin-3-ylamine

: 916983-51-2
5-[5-(2-diethylcarbamoyl-acetylamino)-2,4-bis-octyloxy-benzoylamino]-2,4-bis-octyloxy-benzoic acid

: 916983-52-3
N-{5-[2,4-bis-octyloxy-5-(4-octyloxy-pyridin-3-ylcarbamoyl)-phenylcarbamoyl]-2,4-bis-octyloxy-phenyl}-N',N'-diethyl-malonamide

Guidance literature:: With dicyclohexyl-carbodiimide; In chloroform; at 20 ℃; for 4h;
DOI:10.1016/j.tet.2006.09.046

Reference yield:

: 5435-54-1
4-hydroxy-3-nitropyridine

: 916983-52-3
N-{5-[2,4-bis-octyloxy-5-(4-octyloxy-pyridin-3-ylcarbamoyl)-phenylcarbamoyl]-2,4-bis-octyloxy-phenyl}-N',N'-diethyl-malonamide

Guidance literature:: Multi-step reaction with 4 steps

1: PCl₅ / 1,2-dichloro-ethane / Heating

2: 70 percent / 1,2-dichloro-ethane / 1 h / Heating

3: 90 percent / hydrogen / Pd/C / methanol / 8 h / 20 °C / 760 Torr

4: 78 percent / dicyclohexylcarbodiimide / CHCl₃ / 4 h / 20 °C

With phosphorus pentachloride; hydrogen; dicyclohexyl-carbodiimide; palladium on activated charcoal; In methanol; chloroform; 1,2-dichloro-ethane;
DOI:10.1016/j.tet.2006.09.046

Reference yield:

: 271261-75-7
2,4-dioctyloxy-5-nitrobenzoyl chloride

: 916983-52-3
N-{5-[2,4-bis-octyloxy-5-(4-octyloxy-pyridin-3-ylcarbamoyl)-phenylcarbamoyl]-2,4-bis-octyloxy-phenyl}-N',N'-diethyl-malonamide

Guidance literature:: Multi-step reaction with 5 steps

1: 80 percent / triethylamine / CH₂Cl₂ / 4 h / 20 °C

2: 96 percent / hydrogen / Pd/C / CH₂Cl₂; methanol / 6 h / 20 °C / 760 Torr

3: 80 percent / dicyclohexylcarbodiimide / CH₂Cl₂ / 6 h / 20 °C

4: 90 percent / lithium hydroxide monohydrate / methanol; tetrahydrofuran; H₂O / 12 h / 20 °C

5: 78 percent / dicyclohexylcarbodiimide / CHCl₃ / 4 h / 20 °C

With lithium hydroxide; hydrogen; triethylamine; dicyclohexyl-carbodiimide; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; chloroform; water;
DOI:10.1016/j.tet.2006.09.046