tert-butyl 4-<<2-(pivaloylamino)-4(3H)-oxopteridin-6-yl>ethynyl>benzoate

Base Information

Chemical Name:tert-butyl 4-<<2-(pivaloylamino)-4(3H)-oxopteridin-6-yl>ethynyl>benzoate
CAS No.:111292-01-4
Molecular Formula:C₂₄H₂₅N₅O₄
Molecular Weight:447.494
Hs Code.:

Synonyms:tert-butyl 4-<<2-(pivaloylamino)-4(3H)-oxopteridin-6-yl>ethynyl>benzoate

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Chemical Property of tert-butyl 4-<<2-(pivaloylamino)-4(3H)-oxopteridin-6-yl>ethynyl>benzoate

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Technology Process of tert-butyl 4-<<2-(pivaloylamino)-4(3H)-oxopteridin-6-yl>ethynyl>benzoate

There total 4 articles about tert-butyl 4-<<2-(pivaloylamino)-4(3H)-oxopteridin-6-yl>ethynyl>benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

: 111291-97-5
4-ethynylbenzoic acid tert-butyl ester

: 108473-08-1
N-(6-Chloro-4-hydroxy-pteridin-2-yl)-2,2-dimethyl-propionamide

: 111292-01-4
tert-butyl 4-<<2-(pivaloylamino)-4(3H)-oxopteridin-6-yl>ethynyl>benzoate

Guidance literature:: With copper(l) iodide; palladium diacetate; triethylamine; tris-(o-tolyl)phosphine; In acetonitrile; at 100 ℃; for 16h;
DOI:10.1021/jo00236a009

Reference yield:

: 59247-47-1
tert-butyl-4-bromobenzoate

: 111292-01-4
tert-butyl 4-<<2-(pivaloylamino)-4(3H)-oxopteridin-6-yl>ethynyl>benzoate

Guidance literature:: Multi-step reaction with 3 steps

1: triphenylphosphine, palladium acetate, triethylamine / 12 h / 100 °C

2: potassium carbonate / methanol / 3 h / Ambient temperature

3: 54 percent / palladium acetate, tri-o-tolylphosphine, copper(I) iodide, triethylamine / acetonitrile / 16 h / 100 °C

With copper(l) iodide; palladium diacetate; potassium carbonate; triethylamine; triphenylphosphine; tris-(o-tolyl)phosphine; In methanol; acetonitrile;
DOI:10.1021/jo00236a009

Reference yield:

: 111291-96-4
tert-butyl 4-<(trimethylsilyl)ethynyl>benzoate

: 111292-01-4
tert-butyl 4-<<2-(pivaloylamino)-4(3H)-oxopteridin-6-yl>ethynyl>benzoate

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate / methanol / 3 h / Ambient temperature

2: 54 percent / palladium acetate, tri-o-tolylphosphine, copper(I) iodide, triethylamine / acetonitrile / 16 h / 100 °C

With copper(l) iodide; palladium diacetate; potassium carbonate; triethylamine; tris-(o-tolyl)phosphine; In methanol; acetonitrile;
DOI:10.1021/jo00236a009