Technology Process of C13H16N2O4
There total 5 articles about C13H16N2O4 which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
(2S,4S)-2-acetylacetoxy-4-(2-hydroxyphenoxy)pentane;
With
4-acetamidobenzenesulfonyl azide; triethylamine;
In
acetonitrile;
at 20 ℃;
for 5h;
With
sodium hydroxide;
In
water; acetonitrile;
at 20 ℃;
for 15h;
Further stages.;
DOI:10.1246/cl.2007.314
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: 95 percent / tetrabutylammonium fluoride / tetrahydrofuran / 5 h / 20 °C
2.1: 4-acetamidobenzenesulfonyl azide; Et3N / acetonitrile / 5 h / 20 °C
2.2: 76 percent / NaOH / acetonitrile; H2O / 15 h / 20 °C
With
4-acetamidobenzenesulfonyl azide; tetrabutyl ammonium fluoride; triethylamine;
In
tetrahydrofuran; acetonitrile;
DOI:10.1246/cl.2007.314
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: benzoic acid; triphenylphosphine; diisopropyl azodicarboxylate / tetrahydrofuran / 10 h / 20 °C
1.2: LiAlH4 / diethyl ether / 2 h / 0 °C
2.1: 98 percent / Et3N / CH2Cl2 / 5 h / 20 °C
3.1: 95 percent / tetrabutylammonium fluoride / tetrahydrofuran / 5 h / 20 °C
4.1: 4-acetamidobenzenesulfonyl azide; Et3N / acetonitrile / 5 h / 20 °C
4.2: 76 percent / NaOH / acetonitrile; H2O / 15 h / 20 °C
With
di-isopropyl azodicarboxylate; 4-acetamidobenzenesulfonyl azide; tetrabutyl ammonium fluoride; triethylamine; triphenylphosphine; benzoic acid;
In
tetrahydrofuran; dichloromethane; acetonitrile;
1.1: Mitsunobu reaction;
DOI:10.1246/cl.2007.314
