(1R,3aS,7aR)-4-[2-[(3S,5R)-3,5-Bis-(tert-butyl-dimethyl-silanyloxy)-2-methylene-cyclohex-(Z)-ylidene]-eth-(E)-ylidene]-1-[(1R,5R)-4,4-difluoro-5-(2-methoxy-ethoxymethoxy)-1,5-dimethyl-6-((R)-toluene-4-sulfinyl)-hexyl]-7a-methyl-octahydro-indene

Base Information

Chemical Name:(1R,3aS,7aR)-4-[2-[(3S,5R)-3,5-Bis-(tert-butyl-dimethyl-silanyloxy)-2-methylene-cyclohex-(Z)-ylidene]-eth-(E)-ylidene]-1-[(1R,5R)-4,4-difluoro-5-(2-methoxy-ethoxymethoxy)-1,5-dimethyl-6-((R)-toluene-4-sulfinyl)-hexyl]-7a-methyl-octahydro-indene
CAS No.:219123-57-6
Molecular Formula:C₅₀H₈₄F₂O₆SSi₂
Molecular Weight:907.447
Hs Code.:

(1R,3aS,7aR)-4-[2-[(3S,5R)-3,5-Bis-(tert-butyl-dimethyl-silanyloxy)-2-methylene-cyclohex-(Z)-ylidene]-eth-(E)-ylidene]-1-[(1R,5R)-4,4-difluoro-5-(2-methoxy-ethoxymethoxy)-1,5-dimethyl-6-((R)-toluene-4-sulfinyl)-hexyl]-7a-methyl-octahydro-indene

Synonyms:(1R,3aS,7aR)-4-[2-[(3S,5R)-3,5-Bis-(tert-butyl-dimethyl-silanyloxy)-2-methylene-cyclohex-(Z)-ylidene]-eth-(E)-ylidene]-1-[(1R,5R)-4,4-difluoro-5-(2-methoxy-ethoxymethoxy)-1,5-dimethyl-6-((R)-toluene-4-sulfinyl)-hexyl]-7a-methyl-octahydro-indene

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Chemical Property of (1R,3aS,7aR)-4-[2-[(3S,5R)-3,5-Bis-(tert-butyl-dimethyl-silanyloxy)-2-methylene-cyclohex-(Z)-ylidene]-eth-(E)-ylidene]-1-[(1R,5R)-4,4-difluoro-5-(2-methoxy-ethoxymethoxy)-1,5-dimethyl-6-((R)-toluene-4-sulfinyl)-hexyl]-7a-methyl-octahydro-indene

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Technology Process of (1R,3aS,7aR)-4-[2-[(3S,5R)-3,5-Bis-(tert-butyl-dimethyl-silanyloxy)-2-methylene-cyclohex-(Z)-ylidene]-eth-(E)-ylidene]-1-[(1R,5R)-4,4-difluoro-5-(2-methoxy-ethoxymethoxy)-1,5-dimethyl-6-((R)-toluene-4-sulfinyl)-hexyl]-7a-methyl-octahydro-indene

There total 4 articles about (1R,3aS,7aR)-4-[2-[(3S,5R)-3,5-Bis-(tert-butyl-dimethyl-silanyloxy)-2-methylene-cyclohex-(Z)-ylidene]-eth-(E)-ylidene]-1-[(1R,5R)-4,4-difluoro-5-(2-methoxy-ethoxymethoxy)-1,5-dimethyl-6-((R)-toluene-4-sulfinyl)-hexyl]-7a-methyl-octahydro-indene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 3970-21-6
2-Methoxyethoxymethyl chloride

: 219123-52-1
(2R,6R)-6-{(1R,3aS,7aR)-4-[2-[(3S,5R)-3,5-Bis-(tert-butyl-dimethyl-silanyloxy)-2-methylene-cyclohex-(Z)-ylidene]-eth-(E)-ylidene]-7a-methyl-octahydro-inden-1-yl}-3,3-difluoro-2-methyl-1-((R)-toluene-4-sulfinyl)-heptan-2-ol

: 219123-57-6
(1R,3aS,7aR)-4-[2-[(3S,5R)-3,5-Bis-(tert-butyl-dimethyl-silanyloxy)-2-methylene-cyclohex-(Z)-ylidene]-eth-(E)-ylidene]-1-[(1R,5R)-4,4-difluoro-5-(2-methoxy-ethoxymethoxy)-1,5-dimethyl-6-((R)-toluene-4-sulfinyl)-hexyl]-7a-methyl-octahydro-indene

Guidance literature:: With sodium hydride; In tetrahydrofuran; at 0 ℃; for 2h;
DOI:10.1016/S0040-4020(98)00949-1

Reference yield:

: 1519-39-7
(R)-methyl p-tolyl sulfoxide

: 219123-57-6
(1R,3aS,7aR)-4-[2-[(3S,5R)-3,5-Bis-(tert-butyl-dimethyl-silanyloxy)-2-methylene-cyclohex-(Z)-ylidene]-eth-(E)-ylidene]-1-[(1R,5R)-4,4-difluoro-5-(2-methoxy-ethoxymethoxy)-1,5-dimethyl-6-((R)-toluene-4-sulfinyl)-hexyl]-7a-methyl-octahydro-indene

Guidance literature:: Multi-step reaction with 3 steps

1: 92 percent / diisopropylamine, n-butyllithium / tetrahydrofuran; hexane / 1.) -78 deg C, 15 min, 2.) room temp., 1.5 h

2: 1.) ZnBr₂ / 1.) CH₂Cl₂, room temp., 30 min, 2.) CH₂Cl₂, hexane, -78 deg C, 3 h

3: 76 percent / NaH / tetrahydrofuran / 2 h / 0 °C

With n-butyllithium; sodium hydride; diisopropylamine; zinc dibromide; In tetrahydrofuran; hexane;
DOI:10.1016/S0040-4020(98)00949-1

Reference yield:

: 143884-27-9
(R)-5-{(1R,3aS,7aR)-4-[2-[(3S,5R)-3,5-Bis-(tert-butyl-dimethyl-silanyloxy)-2-methylene-cyclohex-(Z)-ylidene]-eth-(E)-ylidene]-7a-methyl-octahydro-inden-1-yl}-2,2-difluoro-hexanoic acid methyl ester

: 219123-57-6
(1R,3aS,7aR)-4-[2-[(3S,5R)-3,5-Bis-(tert-butyl-dimethyl-silanyloxy)-2-methylene-cyclohex-(Z)-ylidene]-eth-(E)-ylidene]-1-[(1R,5R)-4,4-difluoro-5-(2-methoxy-ethoxymethoxy)-1,5-dimethyl-6-((R)-toluene-4-sulfinyl)-hexyl]-7a-methyl-octahydro-indene

Guidance literature:: Multi-step reaction with 3 steps

1: 92 percent / diisopropylamine, n-butyllithium / tetrahydrofuran; hexane / 1.) -78 deg C, 15 min, 2.) room temp., 1.5 h

2: 1.) ZnBr₂ / 1.) CH₂Cl₂, room temp., 30 min, 2.) CH₂Cl₂, hexane, -78 deg C, 3 h

3: 76 percent / NaH / tetrahydrofuran / 2 h / 0 °C

With n-butyllithium; sodium hydride; diisopropylamine; zinc dibromide; In tetrahydrofuran; hexane;
DOI:10.1016/S0040-4020(98)00949-1