(3R,4R,5R)-3-(4-chlorophenyl)-5-(3,4-dichlorophenyl)-1,3-dimethyl-4-nitropyrazolidine

Base Information

Chemical Name:(3R,4R,5R)-3-(4-chlorophenyl)-5-(3,4-dichlorophenyl)-1,3-dimethyl-4-nitropyrazolidine
CAS No.:1621003-22-2
Molecular Formula:C₁₇H₁₆Cl₃N₃O₂
Molecular Weight:400.692
Hs Code.:

Synonyms:(3R,4R,5R)-3-(4-chlorophenyl)-5-(3,4-dichlorophenyl)-1,3-dimethyl-4-nitropyrazolidine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (3R,4R,5R)-3-(4-chlorophenyl)-5-(3,4-dichlorophenyl)-1,3-dimethyl-4-nitropyrazolidine

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Technology Process of (3R,4R,5R)-3-(4-chlorophenyl)-5-(3,4-dichlorophenyl)-1,3-dimethyl-4-nitropyrazolidine

There total 2 articles about (3R,4R,5R)-3-(4-chlorophenyl)-5-(3,4-dichlorophenyl)-1,3-dimethyl-4-nitropyrazolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 40137-45-9
4'-chloroacetophenone N-methylhydrazone

: 37630-23-2,18984-16-2
1,2-dichloro-4-(2-nitrovinyl)benzene

: 1621003-22-2
(3R,4R,5R)-3-(4-chlorophenyl)-5-(3,4-dichlorophenyl)-1,3-dimethyl-4-nitropyrazolidine

Guidance literature:: With 1-(3,5-bis(trifluoromethyl)phenyl)-3-((S)-3,3-dimethyl-1-oxo-1-((R)-2-phenylpyrrolidin-1-yl)butan-2-yl)thiourea; In toluene; at -30 ℃; for 24h; enantioselective reaction;
DOI:10.1021/ja506694v

Reference yield:

: 99-91-2
para-chloroacetophenone

: 1621003-22-2
(3R,4R,5R)-3-(4-chlorophenyl)-5-(3,4-dichlorophenyl)-1,3-dimethyl-4-nitropyrazolidine

Guidance literature:: Multi-step reaction with 2 steps

1: sodium sulfate; acetic acid / toluene / 90 °C

2: 1-(3,5-bis(trifluoromethyl)phenyl)-3-((S)-3,3-dimethyl-1-oxo-1-((R)-2-phenylpyrrolidin-1-yl)butan-2-yl)thiourea / toluene / 24 h / -30 °C

With 1-(3,5-bis(trifluoromethyl)phenyl)-3-((S)-3,3-dimethyl-1-oxo-1-((R)-2-phenylpyrrolidin-1-yl)butan-2-yl)thiourea; acetic acid; sodium sulfate; In toluene;
DOI:10.1021/ja506694v