6-chloro-N-(7-chloro-2-(oxazol-2-yl)-4-oxo-1-phenyl-1,4-dihydro-quinolin-3-ylmethyl)nicotinamide

Base Information

Chemical Name:6-chloro-N-(7-chloro-2-(oxazol-2-yl)-4-oxo-1-phenyl-1,4-dihydro-quinolin-3-ylmethyl)nicotinamide
CAS No.:1418023-57-0
Molecular Formula:C₂₅H₁₆Cl₂N₄O₃
Molecular Weight:491.333
Hs Code.:

Synonyms:6-chloro-N-(7-chloro-2-(oxazol-2-yl)-4-oxo-1-phenyl-1,4-dihydro-quinolin-3-ylmethyl)nicotinamide

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Chemical Property of 6-chloro-N-(7-chloro-2-(oxazol-2-yl)-4-oxo-1-phenyl-1,4-dihydro-quinolin-3-ylmethyl)nicotinamide

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Technology Process of 6-chloro-N-(7-chloro-2-(oxazol-2-yl)-4-oxo-1-phenyl-1,4-dihydro-quinolin-3-ylmethyl)nicotinamide

There total 7 articles about 6-chloro-N-(7-chloro-2-(oxazol-2-yl)-4-oxo-1-phenyl-1,4-dihydro-quinolin-3-ylmethyl)nicotinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 2.0%

: 6271-78-9
6-chloro-3-pyridinecarboxamide

: 1418025-69-0
3-bromomethyl-7-chloro-2-oxazol-2-yl-1-phenyl-1H-quinolin-4-one

: 1418023-57-0
6-chloro-N-(7-chloro-2-(oxazol-2-yl)-4-oxo-1-phenyl-1,4-dihydro-quinolin-3-ylmethyl)nicotinamide

: 6-chloro-N,N-bis((7-chloro-2-(oxazol-2-yl)-4-oxo-1-phenyl-1,4-dihydro-quinolin-3-yl)methyl)nicotinamide

Guidance literature:: 6-chloro-3-pyridinecarboxamide; With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 50 ℃; for 0.25h; under 760.051 Torr; Inert atmosphere;

3-bromomethyl-7-chloro-2-oxazol-2-yl-1-phenyl-1H-quinolin-4-one; In N,N-dimethyl-formamide; mineral oil; at 50 ℃; for 1h; under 760.051 Torr; Inert atmosphere;

Reference yield:

: 1402345-30-5
4-chloro-N-methoxy-N-methyl-2-phenylamino-benzamide

: 1418023-57-0
6-chloro-N-(7-chloro-2-(oxazol-2-yl)-4-oxo-1-phenyl-1,4-dihydro-quinolin-3-ylmethyl)nicotinamide

: 6-chloro-N,N-bis((7-chloro-2-(oxazol-2-yl)-4-oxo-1-phenyl-1,4-dihydro-quinolin-3-yl)methyl)nicotinamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: tetrahydrofuran / 2 h / 0 - 20 °C / 760.05 Torr / Inert atmosphere

2.1: sodium hexamethyldisilazane / N,N-dimethyl-formamide; tetrahydrofuran / 5 h / 20 °C / 760.05 Torr / Inert atmosphere

3.1: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / tetrachloromethane / 2 h / 760.05 Torr / Inert atmosphere; Reflux

4.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.25 h / 50 °C / 760.05 Torr / Inert atmosphere

4.2: 1 h / 50 °C / 760.05 Torr / Inert atmosphere

With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); sodium hexamethyldisilazane; sodium hydride; In tetrahydrofuran; tetrachloromethane; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 1402345-31-6
1-(4-chloro-2-phenylamino-phenyl)propan-1-one

: 1418023-57-0
6-chloro-N-(7-chloro-2-(oxazol-2-yl)-4-oxo-1-phenyl-1,4-dihydro-quinolin-3-ylmethyl)nicotinamide

: 6-chloro-N,N-bis((7-chloro-2-(oxazol-2-yl)-4-oxo-1-phenyl-1,4-dihydro-quinolin-3-yl)methyl)nicotinamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hexamethyldisilazane / N,N-dimethyl-formamide; tetrahydrofuran / 5 h / 20 °C / 760.05 Torr / Inert atmosphere

2.1: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / tetrachloromethane / 2 h / 760.05 Torr / Inert atmosphere; Reflux

3.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.25 h / 50 °C / 760.05 Torr / Inert atmosphere

3.2: 1 h / 50 °C / 760.05 Torr / Inert atmosphere

With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); sodium hexamethyldisilazane; sodium hydride; In tetrahydrofuran; tetrachloromethane; N,N-dimethyl-formamide; mineral oil;