4-(2-cyclopropylidene-1-methyl-3-phenyl-but-3-enyl)morpholine

Base Information

• Chemical Name: 4-(2-cyclopropylidene-1-methyl-3-phenyl-but-3-enyl)morpholine
• CAS No.: 872028-82-5
• Molecular Formula: C₁₈H₂₃NO
• Molecular Weight: 269.387
• Mol file: 872028-82-5.mol

Synonyms:4-(2-cyclopropylidene-1-methyl-3-phenyl-but-3-enyl)morpholine

Chemical Property of 4-(2-cyclopropylidene-1-methyl-3-phenyl-but-3-enyl)morpholine

Chemical Property:

Purity/Quality:

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Technology Process of 4-(2-cyclopropylidene-1-methyl-3-phenyl-but-3-enyl)morpholine

There total 1 articles about 4-(2-cyclopropylidene-1-methyl-3-phenyl-but-3-enyl)morpholine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 27.0%

morpholine (110-91-8,99108-56-2) + tert-Butyl acrylate (1663-39-4,25232-27-3) + bicyclopropylidene (27567-82-4) + 1-phenyl-1-iodoethylene (51246-20-9) → tert-butyl 8-(1-phenylvinyl)spiro[2.5]oct-7-ene-5-carboxylate + 4-(2-cyclopropylidene-1-methyl-3-phenyl-but-3-enyl)morpholine (872028-82-5) + tert-butyl 8-(1-morpholin-4-ylethyl)-7-phenylspiro[2,5]oct-7-ene-5-carboxylate

Guidance literature:

morpholine; bicyclopropylidene; 1-phenyl-1-iodoethylene; With trifuran-2-yl-phosphane; triethylamine; palladium diacetate; In N,N-dimethyl-formamide; at 80 ℃; for 2h;

tert-Butyl acrylate;

DOI:10.1016/j.tet.2005.09.014

Reference yield: 36.0%

4-(2-cyclopropylidene-1-methyl-3-phenyl-but-3-enyl)morpholine (872028-82-5) + tert-Butyl acrylate (1663-39-4,25232-27-3) → tert-butyl 8-(1-morpholin-4-ylethyl)-7-phenylspiro[2,5]oct-7-ene-5-carboxylate

Guidance literature:

With trifuran-2-yl-phosphane; tetraethyl ammonium; potassium carbonate; palladium diacetate; In acetonitrile; at 100 ℃; for 65h;

DOI:10.1016/j.tet.2005.09.014

Reference yield:

4-(2-cyclopropylidene-1-methyl-3-phenyl-but-3-enyl)morpholine (872028-82-5) + N-phenyl-maleimide (941-69-5) → 5-(1'-(morpholin-4''-yl)ethyl)-2,6-diphenylspiro[cyclopropane-1',4-(3a,4,7,7a)-tetrahydroisoindole]-1,3-dione

Guidance literature:

With trifuran-2-yl-phosphane; triethylamine; palladium diacetate; In N,N-dimethyl-formamide; at 80 ℃; for 4h;

DOI:10.1016/j.tet.2005.09.014

upstream raw materials:

morpholine

tert-Butyl acrylate

bicyclopropylidene

1-phenyl-1-iodoethylene