2-{6-[6-(2-{3-[6-[1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-4-(4-methoxy-benzyloxy)-3,5-dimethyl-tetrahydro-pyran-2-yl]-propenyl}-oxazol-4-yl)-4-triisopropylsilanyloxy-tetrahydro-pyran-2-ylmethyl]-4-methylene-tetrahydro-pyran-2-yl}-ethanol

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Chemical Name:2-{6-[6-(2-{3-[6-[1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-4-(4-methoxy-benzyloxy)-3,5-dimethyl-tetrahydro-pyran-2-yl]-propenyl}-oxazol-4-yl)-4-triisopropylsilanyloxy-tetrahydro-pyran-2-ylmethyl]-4-methylene-tetrahydro-pyran-2-yl}-ethanol
CAS No.:657389-95-2
Molecular Formula:C₅₂H₈₇NO₉Si₂
Molecular Weight:926.435
Hs Code.:

2-{6-[6-(2-{3-[6-[1-(<i>tert</i>-butyl-dimethyl-silanyloxy)-ethyl]-4-(4-methoxy-benzyloxy)-3,5-dimethyl-tetrahydro-pyran-2-yl]-propenyl}-oxazol-4-yl)-4-triisopropylsilanyloxy-tetrahydro-pyran-2-ylmethyl]-4-methylene-tetrahydro-pyran-2-yl}-ethanol

Synonyms:2-{6-[6-(2-{3-[6-[1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-4-(4-methoxy-benzyloxy)-3,5-dimethyl-tetrahydro-pyran-2-yl]-propenyl}-oxazol-4-yl)-4-triisopropylsilanyloxy-tetrahydro-pyran-2-ylmethyl]-4-methylene-tetrahydro-pyran-2-yl}-ethanol

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Chemical Property of 2-{6-[6-(2-{3-[6-[1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-4-(4-methoxy-benzyloxy)-3,5-dimethyl-tetrahydro-pyran-2-yl]-propenyl}-oxazol-4-yl)-4-triisopropylsilanyloxy-tetrahydro-pyran-2-ylmethyl]-4-methylene-tetrahydro-pyran-2-yl}-ethanol

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Technology Process of 2-{6-[6-(2-{3-[6-[1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-4-(4-methoxy-benzyloxy)-3,5-dimethyl-tetrahydro-pyran-2-yl]-propenyl}-oxazol-4-yl)-4-triisopropylsilanyloxy-tetrahydro-pyran-2-ylmethyl]-4-methylene-tetrahydro-pyran-2-yl}-ethanol

There total 7 articles about 2-{6-[6-(2-{3-[6-[1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-4-(4-methoxy-benzyloxy)-3,5-dimethyl-tetrahydro-pyran-2-yl]-propenyl}-oxazol-4-yl)-4-triisopropylsilanyloxy-tetrahydro-pyran-2-ylmethyl]-4-methylene-tetrahydro-pyran-2-yl}-ethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 657389-66-7
C₅₇H₉₅NO₁₀Si₂

: 657389-95-2
2-{6-[6-(2-{3-[6-[1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-4-(4-methoxy-benzyloxy)-3,5-dimethyl-tetrahydro-pyran-2-yl]-propenyl}-oxazol-4-yl)-4-triisopropylsilanyloxy-tetrahydro-pyran-2-ylmethyl]-4-methylene-tetrahydro-pyran-2-yl}-ethanol

Guidance literature:: With lithium hydroxide; In tetrahydrofuran; methanol; at 20 ℃; for 16h;
DOI:10.1039/b308305e

Reference yield:

: 69739-34-0
t-butyldimethylsiyl triflate

: 657389-95-2
2-{6-[6-(2-{3-[6-[1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-4-(4-methoxy-benzyloxy)-3,5-dimethyl-tetrahydro-pyran-2-yl]-propenyl}-oxazol-4-yl)-4-triisopropylsilanyloxy-tetrahydro-pyran-2-ylmethyl]-4-methylene-tetrahydro-pyran-2-yl}-ethanol

Guidance literature:: Multi-step reaction with 5 steps

1.1: 95 percent / 2,6-lutidine / CH₂Cl₂ / 6 h / -78 - 20 °C

2.1: OsO₄; aq. NMO / 2-methyl-propan-2-ol; acetone / 24 h / 20 °C

3.1: 90 mg / NaIO₄; silica / CH₂Cl₂ / 1.5 h

4.1: Bu₃P / dimethylformamide / 24 h / 20 °C

4.2: 99 percent / DBU / dimethylformamide / 0.5 h / 20 °C

5.1: 96 percent / aq. LiOH / methanol; tetrahydrofuran / 16 h / 20 °C

With 2,6-dimethylpyridine; lithium hydroxide; sodium periodate; osmium(VIII) oxide; N-methyl-2-indolinone; tributylphosphine; silica gel; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; acetone; tert-butyl alcohol; 4.2: Wittig reaction;
DOI:10.1039/b308305e

Reference yield:

: (2R,3R,4R,5R)-2-allyl-6-(oxiranyl)-4-(4-methoxy-benzyloxy)-3,5-dimethyltetrahydropyran

: 657389-95-2
2-{6-[6-(2-{3-[6-[1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-4-(4-methoxy-benzyloxy)-3,5-dimethyl-tetrahydro-pyran-2-yl]-propenyl}-oxazol-4-yl)-4-triisopropylsilanyloxy-tetrahydro-pyran-2-ylmethyl]-4-methylene-tetrahydro-pyran-2-yl}-ethanol

Guidance literature:: Multi-step reaction with 6 steps

1.1: 75 percent / LiAlH₄ / diethyl ether / 2 h

2.1: 95 percent / 2,6-lutidine / CH₂Cl₂ / 6 h / -78 - 20 °C

3.1: OsO₄; aq. NMO / 2-methyl-propan-2-ol; acetone / 24 h / 20 °C

4.1: 90 mg / NaIO₄; silica / CH₂Cl₂ / 1.5 h

5.1: Bu₃P / dimethylformamide / 24 h / 20 °C

5.2: 99 percent / DBU / dimethylformamide / 0.5 h / 20 °C

6.1: 96 percent / aq. LiOH / methanol; tetrahydrofuran / 16 h / 20 °C

With 2,6-dimethylpyridine; lithium hydroxide; sodium periodate; osmium(VIII) oxide; lithium aluminium tetrahydride; N-methyl-2-indolinone; tributylphosphine; silica gel; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; N,N-dimethyl-formamide; acetone; tert-butyl alcohol; 5.2: Wittig reaction;
DOI:10.1039/b308305e