sodium (4-methyl-3-triisopropylsilanyloxymethyl-piperazin-1-yl)-acetate

Base Information

Chemical Name:sodium (4-methyl-3-triisopropylsilanyloxymethyl-piperazin-1-yl)-acetate
CAS No.:1443243-89-7
Molecular Formula:C₁₇H₃₅N₂O₃Si*Na
Molecular Weight:366.552
Hs Code.:

Synonyms:sodium (4-methyl-3-triisopropylsilanyloxymethyl-piperazin-1-yl)-acetate

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Chemical Property of sodium (4-methyl-3-triisopropylsilanyloxymethyl-piperazin-1-yl)-acetate

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Technology Process of sodium (4-methyl-3-triisopropylsilanyloxymethyl-piperazin-1-yl)-acetate

There total 1 articles about sodium (4-methyl-3-triisopropylsilanyloxymethyl-piperazin-1-yl)-acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 1443243-88-6
(3-hydroxymethyl-4-methyl-piperazin-1-yl)-acetic acid ethyl ester

: 80522-42-5
triisopropylsilyl trifluoromethanesulfonate

: 1443243-89-7
sodium (4-methyl-3-triisopropylsilanyloxymethyl-piperazin-1-yl)-acetate

Guidance literature:: (3-hydroxymethyl-4-methyl-piperazin-1-yl)-acetic acid ethyl ester; triisopropylsilyl trifluoromethanesulfonate; With triethylamine; In dichloromethane; for 1h;

With sodium hydroxide; In tetrahydrofuran; water; for 18h;

Reference yield:

: 1443243-89-7
sodium (4-methyl-3-triisopropylsilanyloxymethyl-piperazin-1-yl)-acetate

: 1443243-93-3
1-(5-tert-butyl-2-p-tolyl-2H-pyrazol-3-yl)-3-{(1S,4R)-4-[3-(4-methyl-3-triisopropylsilanyloxymethyl-piperazin-1-ylmethyl)-[1,2,4]triazolo[4,3-a]pyridin-6-yloxy]-1,2,3,4-tetrahydro-naphthalen-1-yl}-urea

Guidance literature:: Multi-step reaction with 4 steps

1.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 18 h

2.1: triphenylphosphine; hexachloroethane; triethylamine / tetrahydrofuran / 18 h / 20 °C

3.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.25 h / 20 °C

3.2: 2 h / 60 °C

4.1: N-ethyl-N,N-diisopropylamine / 1,4-dioxane / 18 h / 60 °C

With hexachloroethane; sodium hydride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; triphenylphosphine; In tetrahydrofuran; 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 1443243-89-7
sodium (4-methyl-3-triisopropylsilanyloxymethyl-piperazin-1-yl)-acetate

: 1443240-26-3
1-(5-tert-butyl-2-p-tolyl-2H-pyrazol-3-yl)-3-{(1S,4R)-4-[3-(3-hydroxymethyl-4-methyl-piperazin-1-ylmethyl)-[1,2,4]triazolo[4,3-a]pyridin-6-yloxy]-1,2,3,4-tetrahydro-naphthalen-1-yl}-urea

Guidance literature:: Multi-step reaction with 5 steps

1.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 18 h

2.1: triphenylphosphine; hexachloroethane; triethylamine / tetrahydrofuran / 18 h / 20 °C

3.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.25 h / 20 °C

3.2: 2 h / 60 °C

4.1: N-ethyl-N,N-diisopropylamine / 1,4-dioxane / 18 h / 60 °C

5.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h / 20 °C

With hexachloroethane; tetrabutyl ammonium fluoride; sodium hydride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; triphenylphosphine; In tetrahydrofuran; 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide; mineral oil;