C₄₃H₇₂O₁₀Si₂

Base Information

• Chemical Name: C₄₃H₇₂O₁₀Si₂
• CAS No.: 947597-03-7
• Molecular Formula: C₄₃H₇₂O₁₀Si₂
• Molecular Weight: 805.21
• Mol file: 947597-03-7.mol

Synonyms:C₄₃H₇₂O₁₀Si₂

Chemical Property of C₄₃H₇₂O₁₀Si₂

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₄₃H₇₂O₁₀Si₂

There total 23 articles about C₄₃H₇₂O₁₀Si₂ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C49H86O10Si3 (947596-91-0) → C43H72O10Si2 (947597-03-7)

Guidance literature:

With pyridinium p-toluenesulfonate; In methanol; dichloromethane; at 0 ℃; for 2h;

DOI:10.1021/ja073590a

Reference yield:

(S)-2-(dimethoxymethyl)-1-(2-thioxothiazolidin-3-yl)pent-4-en-1-one (947596-85-2) → C43H72O10Si2 (947597-03-7)

Guidance literature:

Multi-step reaction with 18 steps

1.1: isopropylmagnesium chloride / tetrahydrofuran; CH₂Cl₂ / 0.25 h / 20 °C

1.2: tetrahydrofuran; CH₂Cl₂ / 18 h / 65 °C

2.1: LiHMDS / diethyl ether / 0.25 h / 0 °C

2.2: diethyl ether / 24 h / 0 - 20 °C

3.1: Fe(acac)3 / tetrahydrofuran; 1-methyl-pyrrolidin-2-one / -20 °C

4.1: DIBAL-H / CH₂Cl₂ / 0.33 h / -78 °C

5.1: MnO₂ / diethyl ether / 19 h / 20 °C

6.1: Sn(OTf)2; N-ethylpiperidine / CH₂Cl₂ / 4 h / -55 °C

6.2: CH₂Cl₂ / 0.5 h / -78 °C

7.1: 2,6-lutidine / CH₂Cl₂ / 0.25 h / 0 °C

8.1: K₂CO₃ / 6 h / 0 - 20 °C

9.1: OsO₄; aq. NMO / acetone; tetrahydrofuran; 2-methyl-propan-2-ol / 0 - 20 °C

10.1: NaIO₄ / tetrahydrofuran / 1 h / 0 °C / pH 7

11.1: Zn(OTf)2; (-)-N-Me-ephedrine; Et₃N / toluene / 0.5 h / 20 °C

11.2: toluene / 0.33 h / 20 °C

12.1: NaHMDS / tetrahydrofuran; dimethylformamide / 0.5 h / -78 °C

13.1: H₂; quinoline / Pd/CaCO₃ / benzene / 2 h

14.1: K₂OsO₄; aq. NMO; citric acid / 2-methyl-propan-2-ol / 24 h / 60 °C

15.1: K₂CO₃; Pb(OAc)4 / CH₂Cl₂ / 0.33 h / 0 °C

16.1: n-BuLi / hexane; diethyl ether / 0.25 h / -78 °C

16.2: MgBr₂*OEt₂ / hexane; diethyl ether / 0.17 h / -78 °C

16.3: MgBr₂*OEt₂ / hexane; CH₂Cl₂; diethyl ether / 1.67 h / -78 - -15 °C

17.1: 2,6-lutidine / CH₂Cl₂ / 0.33 h / 0 °C

18.1: PPTS / methanol; CH₂Cl₂ / 2 h / 0 °C

With 1-ethyl-piperidine; 2,6-dimethylpyridine; quinoline; lead(IV) acetate; manganese(IV) oxide; potassium osmate(VI); sodium periodate; osmium(VIII) oxide; tin(II) trifluoromethanesulfonate; n-butyllithium; N-methyl-2-indolinone; iron(III)-acetylacetonate; (-)-N-methylephedrine; hydrogen; isopropylmagnesium chloride; sodium hexamethyldisilazane; pyridinium p-toluenesulfonate; zinc trifluoromethanesulfonate; diisobutylaluminium hydride; potassium carbonate; triethylamine; citric acid; lithium hexamethyldisilazane; Lindlar's catalyst; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; methanol; diethyl ether; hexane; dichloromethane; N,N-dimethyl-formamide; acetone; toluene; tert-butyl alcohol; benzene; 1.2: Claisen condensation;

DOI:10.1021/ja073590a

Reference yield:

(3R,6R,E)-6-(dimethoxymethyl)-3-hydroxy-1-((S)-4-isopropyl-2-thioxothiazolidin-3-yl)-5-methylnona-4,8-dien-1-one (947597-08-2) → C43H72O10Si2 (947597-03-7)

Guidance literature:

Multi-step reaction with 12 steps

1.1: 2,6-lutidine / CH₂Cl₂ / 0.25 h / 0 °C

2.1: K₂CO₃ / 6 h / 0 - 20 °C

3.1: OsO₄; aq. NMO / acetone; tetrahydrofuran; 2-methyl-propan-2-ol / 0 - 20 °C

4.1: NaIO₄ / tetrahydrofuran / 1 h / 0 °C / pH 7

5.1: Zn(OTf)2; (-)-N-Me-ephedrine; Et₃N / toluene / 0.5 h / 20 °C

5.2: toluene / 0.33 h / 20 °C

6.1: NaHMDS / tetrahydrofuran; dimethylformamide / 0.5 h / -78 °C

7.1: H₂; quinoline / Pd/CaCO₃ / benzene / 2 h

8.1: K₂OsO₄; aq. NMO; citric acid / 2-methyl-propan-2-ol / 24 h / 60 °C

9.1: K₂CO₃; Pb(OAc)4 / CH₂Cl₂ / 0.33 h / 0 °C

10.1: n-BuLi / hexane; diethyl ether / 0.25 h / -78 °C

10.2: MgBr₂*OEt₂ / hexane; diethyl ether / 0.17 h / -78 °C

10.3: MgBr₂*OEt₂ / hexane; CH₂Cl₂; diethyl ether / 1.67 h / -78 - -15 °C

11.1: 2,6-lutidine / CH₂Cl₂ / 0.33 h / 0 °C

12.1: PPTS / methanol; CH₂Cl₂ / 2 h / 0 °C

With 2,6-dimethylpyridine; quinoline; lead(IV) acetate; potassium osmate(VI); sodium periodate; osmium(VIII) oxide; n-butyllithium; N-methyl-2-indolinone; (-)-N-methylephedrine; hydrogen; sodium hexamethyldisilazane; pyridinium p-toluenesulfonate; zinc trifluoromethanesulfonate; potassium carbonate; triethylamine; citric acid; Lindlar's catalyst; In tetrahydrofuran; methanol; diethyl ether; hexane; dichloromethane; N,N-dimethyl-formamide; acetone; toluene; tert-butyl alcohol; benzene;

DOI:10.1021/ja073590a

upstream raw materials:

C₄₉H₈₆O₁₀Si₃

(S)-2-(dimethoxymethyl)-1-(2-thioxothiazolidin-3-yl)pent-4-en-1-one

(S)-1-(furan-3-yl)but-3-yn-1-ol

furan-3-carboxaldehyde

Downstream raw materials:

C₄₂H₆₈O₉Si₂

C₃₀H₄₀O₉