ethyl (3R)-3-[(tert-butoxycarbonyl)amino]-2,2-difluoro-4-phenylbutanoate

Base Information

Chemical Name:ethyl (3R)-3-[(tert-butoxycarbonyl)amino]-2,2-difluoro-4-phenylbutanoate
CAS No.:676460-46-1
Molecular Formula:C₁₇H₂₃F₂NO₄
Molecular Weight:343.371
Hs Code.:

Synonyms:ethyl (3R)-3-[(tert-butoxycarbonyl)amino]-2,2-difluoro-4-phenylbutanoate

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Chemical Property of ethyl (3R)-3-[(tert-butoxycarbonyl)amino]-2,2-difluoro-4-phenylbutanoate

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Technology Process of ethyl (3R)-3-[(tert-butoxycarbonyl)amino]-2,2-difluoro-4-phenylbutanoate

There total 3 articles about ethyl (3R)-3-[(tert-butoxycarbonyl)amino]-2,2-difluoro-4-phenylbutanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

: 24424-99-5
di-tert-butyl dicarbonate

: 676460-45-0
ethyl (3R)-2,2-difluoro-3-{N-[(1R)-(2-methoxy-1-phenylethyl)]amino}-4-phenylbutanoate

: 676460-46-1
ethyl (3R)-3-[(tert-butoxycarbonyl)amino]-2,2-difluoro-4-phenylbutanoate

Guidance literature:: ethyl (3R)-2,2-difluoro-3-{N-[(1R)-(2-methoxy-1-phenylethyl)]amino}-4-phenylbutanoate; With hydrogen; palladium hydroxide - carbon; In ethanol; at 20 ℃;

di-tert-butyl dicarbonate; In tetrahydrofuran; Heating;
DOI:10.1021/jo035709d

Reference yield:

: 122-78-1
phenylacetaldehyde

: 676460-46-1
ethyl (3R)-3-[(tert-butoxycarbonyl)amino]-2,2-difluoro-4-phenylbutanoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: tetrahydrofuran / 0 °C

2.1: 490 mg / Et₂Zn / RhCl(PPh₃)3 / tetrahydrofuran; hexane / 0.5 h / 0 °C

3.1: H₂ / (Pd(OH)2/C / ethanol / 20 °C

3.2: 51 percent / tetrahydrofuran / Heating

With hydrogen; diethylzinc; palladium hydroxide - carbon; RhCl(PPh₃)3; In tetrahydrofuran; ethanol; hexane;
DOI:10.1021/jo035709d

Reference yield:

: ((R)-2-Methoxy-1-phenyl-ethyl)-[2-phenyl-eth-(E)-ylidene]-amine

: 676460-46-1
ethyl (3R)-3-[(tert-butoxycarbonyl)amino]-2,2-difluoro-4-phenylbutanoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: 490 mg / Et₂Zn / RhCl(PPh₃)3 / tetrahydrofuran; hexane / 0.5 h / 0 °C

2.1: H₂ / (Pd(OH)2/C / ethanol / 20 °C

2.2: 51 percent / tetrahydrofuran / Heating

With hydrogen; diethylzinc; palladium hydroxide - carbon; RhCl(PPh₃)3; In tetrahydrofuran; ethanol; hexane;
DOI:10.1021/jo035709d