[(2S)-1-{[1-(3-ethoxyphenyl)-2-(2-fluoro-4-methylphenyl)-1H-imidazol-4-yl]carbonyl}-4-(4-{[(triisopropylsilyl)oxy]methyl}-2-naphthyl)piperazin-2-yl]methyl acetate

Base Information

Chemical Name:[(2S)-1-{[1-(3-ethoxyphenyl)-2-(2-fluoro-4-methylphenyl)-1H-imidazol-4-yl]carbonyl}-4-(4-{[(triisopropylsilyl)oxy]methyl}-2-naphthyl)piperazin-2-yl]methyl acetate
CAS No.:954410-06-1
Molecular Formula:C₄₆H₅₇FN₄O₅Si
Molecular Weight:793.066
Hs Code.:

[(2S)-1-{[1-(3-ethoxyphenyl)-2-(2-fluoro-4-methylphenyl)-1H-imidazol-4-yl]carbonyl}-4-(4-{[(triisopropylsilyl)oxy]methyl}-2-naphthyl)piperazin-2-yl]methyl acetate

Synonyms:[(2S)-1-{[1-(3-ethoxyphenyl)-2-(2-fluoro-4-methylphenyl)-1H-imidazol-4-yl]carbonyl}-4-(4-{[(triisopropylsilyl)oxy]methyl}-2-naphthyl)piperazin-2-yl]methyl acetate

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Chemical Property of [(2S)-1-{[1-(3-ethoxyphenyl)-2-(2-fluoro-4-methylphenyl)-1H-imidazol-4-yl]carbonyl}-4-(4-{[(triisopropylsilyl)oxy]methyl}-2-naphthyl)piperazin-2-yl]methyl acetate

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Technology Process of [(2S)-1-{[1-(3-ethoxyphenyl)-2-(2-fluoro-4-methylphenyl)-1H-imidazol-4-yl]carbonyl}-4-(4-{[(triisopropylsilyl)oxy]methyl}-2-naphthyl)piperazin-2-yl]methyl acetate

There total 6 articles about [(2S)-1-{[1-(3-ethoxyphenyl)-2-(2-fluoro-4-methylphenyl)-1H-imidazol-4-yl]carbonyl}-4-(4-{[(triisopropylsilyl)oxy]methyl}-2-naphthyl)piperazin-2-yl]methyl acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 4507-84-0
3-nitro-1-naphthoic acid

: 954410-06-1
[(2S)-1-{[1-(3-ethoxyphenyl)-2-(2-fluoro-4-methylphenyl)-1H-imidazol-4-yl]carbonyl}-4-(4-{[(triisopropylsilyl)oxy]methyl}-2-naphthyl)piperazin-2-yl]methyl acetate

Guidance literature:: Multi-step reaction with 7 steps

1.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 3 h / 0 - 20 °C

2.1: dichloromethane / 1 h

3.1: hydrogen / palladium 10% on activated carbon / ethanol; dichloromethane / 3 h / 2068.65 Torr

4.1: hydrogen bromide; sodium nitrite / ethanol; water / 0.5 h / 0 °C

4.2: 0.83 h / 0 - 95 °C

5.1: diisobutylaluminium hydride / tetrahydrofuran; toluene / 1.5 h / -78 - 20 °C

5.2: 2 h / 0 - 20 °C

6.1: 1H-imidazole; dmap / N,N-dimethyl-formamide / 15 h / 20 °C

7.1: caesium carbonate; DavePhos / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane / 15 h / 85 °C

With 1H-imidazole; dmap; oxalyl dichloride; hydrogen bromide; hydrogen; diisobutylaluminium hydride; caesium carbonate; N,N-dimethyl-formamide; DavePhos; sodium nitrite; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; palladium 10% on activated carbon; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; water; N,N-dimethyl-formamide; toluene;

Reference yield:

: 13772-63-9
methyl 3-nitro-5,6,7,8-tetrahydro-1-naphthoate

: 954410-06-1
[(2S)-1-{[1-(3-ethoxyphenyl)-2-(2-fluoro-4-methylphenyl)-1H-imidazol-4-yl]carbonyl}-4-(4-{[(triisopropylsilyl)oxy]methyl}-2-naphthyl)piperazin-2-yl]methyl acetate

Guidance literature:: Multi-step reaction with 5 steps

1.1: hydrogen / palladium 10% on activated carbon / ethanol; dichloromethane / 3 h / 2068.65 Torr

2.1: hydrogen bromide; sodium nitrite / ethanol; water / 0.5 h / 0 °C

2.2: 0.83 h / 0 - 95 °C

3.1: diisobutylaluminium hydride / tetrahydrofuran; toluene / 1.5 h / -78 - 20 °C

3.2: 2 h / 0 - 20 °C

4.1: 1H-imidazole; dmap / N,N-dimethyl-formamide / 15 h / 20 °C

5.1: caesium carbonate; DavePhos / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane / 15 h / 85 °C

With 1H-imidazole; dmap; hydrogen bromide; hydrogen; diisobutylaluminium hydride; caesium carbonate; DavePhos; sodium nitrite; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; palladium 10% on activated carbon; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; water; N,N-dimethyl-formamide; toluene;

Reference yield:

: 16650-63-8
3-bromo-naphthalene-1-carboxylic acid methyl ester

: 954410-06-1
[(2S)-1-{[1-(3-ethoxyphenyl)-2-(2-fluoro-4-methylphenyl)-1H-imidazol-4-yl]carbonyl}-4-(4-{[(triisopropylsilyl)oxy]methyl}-2-naphthyl)piperazin-2-yl]methyl acetate

Guidance literature:: Multi-step reaction with 3 steps

1.1: diisobutylaluminium hydride / tetrahydrofuran; toluene / 1.5 h / -78 - 20 °C

1.2: 2 h / 0 - 20 °C

2.1: 1H-imidazole; dmap / N,N-dimethyl-formamide / 15 h / 20 °C

3.1: caesium carbonate; DavePhos / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane / 15 h / 85 °C

With 1H-imidazole; dmap; diisobutylaluminium hydride; caesium carbonate; DavePhos; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; N,N-dimethyl-formamide; toluene;