(S)-ethyl 2-(4-(((R)-3-((R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl)thiazolidine-2-carboxamido)methyl)phenylamino)-3-methylbutanoate hydrochloride

Base Information

Chemical Name:(S)-ethyl 2-(4-(((R)-3-((R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl)thiazolidine-2-carboxamido)methyl)phenylamino)-3-methylbutanoate hydrochloride
CAS No.:1041609-53-3
Molecular Formula:C₂₈H₃₅F₃N₄O₄S*ClH
Molecular Weight:617.132
Hs Code.:

(S)-ethyl 2-(4-(((R)-3-((R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl)thiazolidine-2-carboxamido)methyl)phenylamino)-3-methylbutanoate hydrochloride

Synonyms:(S)-ethyl 2-(4-(((R)-3-((R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl)thiazolidine-2-carboxamido)methyl)phenylamino)-3-methylbutanoate hydrochloride

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Chemical Property of (S)-ethyl 2-(4-(((R)-3-((R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl)thiazolidine-2-carboxamido)methyl)phenylamino)-3-methylbutanoate hydrochloride

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Technology Process of (S)-ethyl 2-(4-(((R)-3-((R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl)thiazolidine-2-carboxamido)methyl)phenylamino)-3-methylbutanoate hydrochloride

There total 12 articles about (S)-ethyl 2-(4-(((R)-3-((R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl)thiazolidine-2-carboxamido)methyl)phenylamino)-3-methylbutanoate hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₃₃H₄₃F₃N₄O₆S

: 1041609-53-3
(S)-ethyl 2-(4-(((R)-3-((R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl)thiazolidine-2-carboxamido)methyl)phenylamino)-3-methylbutanoate hydrochloride

Guidance literature:: With water; lithium hydroxide; In tetrahydrofuran; methanol; at 20 ℃; for 3h;
DOI:10.1016/j.bmcl.2011.01.041

Reference yield:

: C₁₂H₁₄N₂O₂

: 1041609-53-3
(S)-ethyl 2-(4-(((R)-3-((R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl)thiazolidine-2-carboxamido)methyl)phenylamino)-3-methylbutanoate hydrochloride

Guidance literature:: Multi-step reaction with 6 steps

1: potassium carbonate / acetone / 2 h

2: sodium tetrahydroborate; nickel dichloride / ethanol / 0.33 h / 20 °C

3: sodium hydrogencarbonate / 3 h / 20 °C

4: hydrogenchloride; water / 1,4-dioxane / 12 h / 20 °C

5: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / dichloromethane / 10 h / 20 °C

6: water; lithium hydroxide / tetrahydrofuran; methanol / 3 h / 20 °C

With hydrogenchloride; sodium tetrahydroborate; water; sodium hydrogencarbonate; potassium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; nickel dichloride; lithium hydroxide; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; dichloromethane; acetone;
DOI:10.1016/j.bmcl.2011.01.041

Reference yield:

: 1041612-25-2
(S)-ethyl 2-(4-cyanophenylamino)-3-methylbutanoate

: 1041609-53-3
(S)-ethyl 2-(4-(((R)-3-((R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl)thiazolidine-2-carboxamido)methyl)phenylamino)-3-methylbutanoate hydrochloride

Guidance literature:: Multi-step reaction with 5 steps

1: sodium tetrahydroborate; nickel dichloride / ethanol / 0.33 h / 20 °C

2: sodium hydrogencarbonate / 3 h / 20 °C

3: hydrogenchloride; water / 1,4-dioxane / 12 h / 20 °C

4: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / dichloromethane / 10 h / 20 °C

5: water; lithium hydroxide / tetrahydrofuran; methanol / 3 h / 20 °C

With hydrogenchloride; sodium tetrahydroborate; water; sodium hydrogencarbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; nickel dichloride; lithium hydroxide; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; dichloromethane;
DOI:10.1016/j.bmcl.2011.01.041