3,3,3-trifluoro-N-(2-formyl-4-methoxyphenyl)propanamide

Base Information

Chemical Name:3,3,3-trifluoro-N-(2-formyl-4-methoxyphenyl)propanamide
CAS No.:1371589-17-1
Molecular Formula:C₁₁H₁₀F₃NO₃
Molecular Weight:261.201
Hs Code.:

Synonyms:3,3,3-trifluoro-N-(2-formyl-4-methoxyphenyl)propanamide

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Chemical Property of 3,3,3-trifluoro-N-(2-formyl-4-methoxyphenyl)propanamide

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Technology Process of 3,3,3-trifluoro-N-(2-formyl-4-methoxyphenyl)propanamide

There total 6 articles about 3,3,3-trifluoro-N-(2-formyl-4-methoxyphenyl)propanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 1371589-15-9
3,3,3-trifluoro-N-(2-(hydroxymethyl)-4-methoxyphenyl)propanamide

: 1371589-17-1
3,3,3-trifluoro-N-(2-formyl-4-methoxyphenyl)propanamide

Guidance literature:: With manganese(IV) oxide; In dichloromethane; for 16h; Reflux;

Reference yield:

: 1882-69-5
5-methoxy-2-nitro-benzoic acid

: 1371589-17-1
3,3,3-trifluoro-N-(2-formyl-4-methoxyphenyl)propanamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: thionyl chloride / tetrahydrofuran / 4 h / Reflux

1.2: 3.5 h / 0 - 30 °C

1.3: pH 8 / Cooling with ice

2.1: 1H-imidazole / N,N-dimethyl-formamide; tetrahydrofuran / 2 h / 0 - 30 °C

2.2: Cooling with ice

3.1: hydrogen / palladium 10% on activated carbon / ethanol / 2 h / 30 °C / 2068.65 Torr

4.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; 4-methyl-morpholine / dichloromethane / 2 h / 20 °C

5.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.5 h / 35 °C

5.2: Cooling with ice

6.1: manganese(IV) oxide / dichloromethane / 16 h / Reflux

With 4-methyl-morpholine; 1H-imidazole; manganese(IV) oxide; thionyl chloride; tetrabutyl ammonium fluoride; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; palladium 10% on activated carbon; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 879-55-0
(5-methoxy-2'-nitrophenyl)methanol

: 1371589-17-1
3,3,3-trifluoro-N-(2-formyl-4-methoxyphenyl)propanamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: 1H-imidazole / N,N-dimethyl-formamide; tetrahydrofuran / 2 h / 0 - 30 °C

1.2: Cooling with ice

2.1: hydrogen / palladium 10% on activated carbon / ethanol / 2 h / 30 °C / 2068.65 Torr

3.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; 4-methyl-morpholine / dichloromethane / 2 h / 20 °C

4.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.5 h / 35 °C

4.2: Cooling with ice

5.1: manganese(IV) oxide / dichloromethane / 16 h / Reflux

With 4-methyl-morpholine; 1H-imidazole; manganese(IV) oxide; tetrabutyl ammonium fluoride; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; palladium 10% on activated carbon; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide;