(R)-tert-butyl 4-(5-bromo-2-fluorophenyl)-4-methyl-1,2,3-oxathiazolidine-3-carboxylate 2,2-dioxide

Base Information

Chemical Name:(R)-tert-butyl 4-(5-bromo-2-fluorophenyl)-4-methyl-1,2,3-oxathiazolidine-3-carboxylate 2,2-dioxide
CAS No.:1313525-81-3
Molecular Formula:C₁₄H₁₇BrFNO₅S
Molecular Weight:410.261
Hs Code.:

Synonyms:(R)-tert-butyl 4-(5-bromo-2-fluorophenyl)-4-methyl-1,2,3-oxathiazolidine-3-carboxylate 2,2-dioxide

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Chemical Property of (R)-tert-butyl 4-(5-bromo-2-fluorophenyl)-4-methyl-1,2,3-oxathiazolidine-3-carboxylate 2,2-dioxide

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Technology Process of (R)-tert-butyl 4-(5-bromo-2-fluorophenyl)-4-methyl-1,2,3-oxathiazolidine-3-carboxylate 2,2-dioxide

There total 10 articles about (R)-tert-butyl 4-(5-bromo-2-fluorophenyl)-4-methyl-1,2,3-oxathiazolidine-3-carboxylate 2,2-dioxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: ruthenium (III) chloride hydrate

: 1313525-80-2
rac-[1-(5-bromo-2-fluoro-phenyl)-2-hydroxy-1-methyl-ethyl]-carbamic acid tert-butyl ester

: 1313525-81-3
(R)-tert-butyl 4-(5-bromo-2-fluorophenyl)-4-methyl-1,2,3-oxathiazolidine-3-carboxylate 2,2-dioxide

Guidance literature:: With pyridine; hydrogenchloride; thionyl chloride; In water;

Reference yield:

: C₁₄H₁₇BrFNO₄S

: 1313525-81-3
(R)-tert-butyl 4-(5-bromo-2-fluorophenyl)-4-methyl-1,2,3-oxathiazolidine-3-carboxylate 2,2-dioxide

Guidance literature:: With sodium periodate; rhodium(III) chloride hydrate; In water; acetonitrile; at 0 - 25 ℃; for 1h;

Reference yield:

: 198477-89-3
1-(5-bromo-2-fluorophenyl)ethan-1-one

: 1313525-81-3
(R)-tert-butyl 4-(5-bromo-2-fluorophenyl)-4-methyl-1,2,3-oxathiazolidine-3-carboxylate 2,2-dioxide

Guidance literature:: Multi-step reaction with 7 steps

1.1: ammonium hydroxide; ammonium chloride / water / 20 °C

1.2: Reflux

2.1: hydrogenchloride; water / Reflux

3.1: sodium hydroxide / water

4.1: dimethylsulfide borane complex / tetrahydrofuran / 5 h / Reflux

5.1: sodium hydrogencarbonate / 1,4-dioxane; water

6.1: thionyl chloride; pyridine / dichloromethane / 16 h / 0 - 25 °C

7.1: sodium periodate / rhodium(III) chloride hydrate / acetonitrile; water / 1 h / 0 - 25 °C

With pyridine; hydrogenchloride; ammonium hydroxide; sodium periodate; thionyl chloride; dimethylsulfide borane complex; water; sodium hydrogencarbonate; ammonium chloride; sodium hydroxide; rhodium(III) chloride hydrate; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; acetonitrile;