8-{1-[1-(2,4-difluoro-phenyl)-5-oxo-pyrrolidin-3-ylmethyl]-1H-pyrazol-4-yl}-1-propyl-1,7-dihydro-purin-6-one

Base Information

Chemical Name:8-{1-[1-(2,4-difluoro-phenyl)-5-oxo-pyrrolidin-3-ylmethyl]-1H-pyrazol-4-yl}-1-propyl-1,7-dihydro-purin-6-one
CAS No.:1243707-69-8
Molecular Formula:C₂₂H₂₁F₂N₇O₂
Molecular Weight:453.451
Hs Code.:

Synonyms:8-{1-[1-(2,4-difluoro-phenyl)-5-oxo-pyrrolidin-3-ylmethyl]-1H-pyrazol-4-yl}-1-propyl-1,7-dihydro-purin-6-one

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Chemical Property of 8-{1-[1-(2,4-difluoro-phenyl)-5-oxo-pyrrolidin-3-ylmethyl]-1H-pyrazol-4-yl}-1-propyl-1,7-dihydro-purin-6-one

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Technology Process of 8-{1-[1-(2,4-difluoro-phenyl)-5-oxo-pyrrolidin-3-ylmethyl]-1H-pyrazol-4-yl}-1-propyl-1,7-dihydro-purin-6-one

There total 4 articles about 8-{1-[1-(2,4-difluoro-phenyl)-5-oxo-pyrrolidin-3-ylmethyl]-1H-pyrazol-4-yl}-1-propyl-1,7-dihydro-purin-6-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 33.0%

: 1243708-26-0
2-chloro-8-{1-[1-(2,4-difluoro-phenyl)-5-oxo-pyrrolidin-3-ylmethyl]-1H-pyrazol-4-yl}-1-propyl-1,7-dihydro-purin-6-one

: 1243707-69-8
8-{1-[1-(2,4-difluoro-phenyl)-5-oxo-pyrrolidin-3-ylmethyl]-1H-pyrazol-4-yl}-1-propyl-1,7-dihydro-purin-6-one

Guidance literature:: With ammonium formate; palladium 10% on activated carbon; In water; N,N-dimethyl-formamide; at 85 - 90 ℃; for 1h;

Reference yield:

: 1243708-21-5
Methanesulfonic acid 1-(2,4-difluoro-phenyl)-5-oxo-pyrrolidin-3-ylmethyl ester

: 1243707-69-8
8-{1-[1-(2,4-difluoro-phenyl)-5-oxo-pyrrolidin-3-ylmethyl]-1H-pyrazol-4-yl}-1-propyl-1,7-dihydro-purin-6-one

Guidance literature:: Multi-step reaction with 5 steps

1: potassium carbonate / N,N-dimethyl-formamide / 20 h / 55 - 60 °C

2: potassium hydroxide; water / methanol / 3 h / 50 - 55 °C

3: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / methanol / 20 h / 0 - 25 °C

4: O-phenyl phosphorodichloridate / methanol / 30 h / 125 - 130 °C

5: ammonium formate / palladium 10% on activated carbon / N,N-dimethyl-formamide; water / 1 h / 85 - 90 °C

With water; ammonium formate; potassium carbonate; O-phenyl phosphorodichloridate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; potassium hydroxide; palladium 10% on activated carbon; In methanol; water; N,N-dimethyl-formamide;

Reference yield:

: 1243708-19-1
1-[1-(2,4-difluoro-phenyl)-5-oxo-pyrrolidin-3-ylmethyl]-1H-pyrazole-4-carboxylic acid ethyl ester

: 1243707-69-8
8-{1-[1-(2,4-difluoro-phenyl)-5-oxo-pyrrolidin-3-ylmethyl]-1H-pyrazol-4-yl}-1-propyl-1,7-dihydro-purin-6-one

Guidance literature:: Multi-step reaction with 4 steps

1: potassium hydroxide; water / methanol / 3 h / 50 - 55 °C

2: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / methanol / 20 h / 0 - 25 °C

3: O-phenyl phosphorodichloridate / methanol / 30 h / 125 - 130 °C

4: ammonium formate / palladium 10% on activated carbon / N,N-dimethyl-formamide; water / 1 h / 85 - 90 °C

With water; ammonium formate; O-phenyl phosphorodichloridate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; potassium hydroxide; palladium 10% on activated carbon; In methanol; water; N,N-dimethyl-formamide;