N¹-[[[bis-5''-(phenylthio)phosphoryl]oxyethoxy]methyl]-5'-O-dianilinophosphoryl-2',3'-O-isopropylidene-8-azidoinosine

Base Information

• Chemical Name: N¹-[[[bis-5''-(phenylthio)phosphoryl]oxyethoxy]methyl]-5'-O-dianilinophosphoryl-2',3'-O-isopropylidene-8-azidoinosine
• CAS No.: 799815-65-9
• Molecular Formula: C₄₀H₄₁N₉O₉P₂S₂
• Molecular Weight: 917.9

Synonyms:N¹-[[[bis-5''-(phenylthio)phosphoryl]oxyethoxy]methyl]-5'-O-dianilinophosphoryl-2',3'-O-isopropylidene-8-azidoinosine

Chemical Property of N¹-[[[bis-5''-(phenylthio)phosphoryl]oxyethoxy]methyl]-5'-O-dianilinophosphoryl-2',3'-O-isopropylidene-8-azidoinosine

Chemical Property:

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Technology Process of N¹-[[[bis-5''-(phenylthio)phosphoryl]oxyethoxy]methyl]-5'-O-dianilinophosphoryl-2',3'-O-isopropylidene-8-azidoinosine

There total 3 articles about N¹-[[[bis-5''-(phenylthio)phosphoryl]oxyethoxy]methyl]-5'-O-dianilinophosphoryl-2',3'-O-isopropylidene-8-azidoinosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

8-bromo-N1-[(2-acetoxyethoxy)-methyl]-5'-O-dianilinophosphoryl-2',3'-O-isopropylideneinosine (444989-16-6) → N1-[[[bis-5''-(phenylthio)phosphoryl]oxyethoxy]methyl]-5'-O-dianilinophosphoryl-2',3'-O-isopropylidene-8-azidoinosine (799815-65-9)

Guidance literature:

Multi-step reaction with 3 steps

1: 90 percent / NaN₃ / dimethylsulfoxide / 12 h / 80 °C

2: MeONa; MeOH / 2 h / 20 °C

3: 237 mg / pyridine; triisopropylbenzenesulfonyl chloride; tetrazole / 12 h / 20 °C

With pyridine; 1H-tetrazole; methanol; sodium azide; triisopropylbenzenesulfonyl chloride; sodium methylate; In dimethyl sulfoxide;

DOI:10.1021/jm040092t

Reference yield:

cyclohexylammonium S,S-diphenyl phosphorodithioate (67941-87-1) + C28H32N9O8P (1053624-81-9) → N1-[[[bis-5''-(phenylthio)phosphoryl]oxyethoxy]methyl]-5'-O-dianilinophosphoryl-2',3'-O-isopropylidene-8-azidoinosine (799815-65-9)

Guidance literature:

With pyridine; 1H-tetrazole; triisopropylbenzenesulfonyl chloride; at 20 ℃; for 12h;

DOI:10.1021/jm040092t

Reference yield:

C30H34N9O9P (799815-62-6) → N1-[[[bis-5''-(phenylthio)phosphoryl]oxyethoxy]methyl]-5'-O-dianilinophosphoryl-2',3'-O-isopropylidene-8-azidoinosine (799815-65-9)

Guidance literature:

Multi-step reaction with 2 steps

1: MeONa; MeOH / 2 h / 20 °C

2: 237 mg / pyridine; triisopropylbenzenesulfonyl chloride; tetrazole / 12 h / 20 °C

With pyridine; 1H-tetrazole; methanol; triisopropylbenzenesulfonyl chloride; sodium methylate;

DOI:10.1021/jm040092t

upstream raw materials:

cyclohexylammonium S,S-diphenyl phosphorodithioate

C₂₈H₃₂N₉O₈P

8-bromo-N¹-[(2-acetoxyethoxy)-methyl]-5'-O-dianilinophosphoryl-2',3'-O-isopropylideneinosine

C₃₀H₃₄N₉O₉P

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