(2-bromo-5-trifluoromethylphenyl)(6,7-methylenedioxyisoquinolin-1-yl)methanone

Base Information

Chemical Name:(2-bromo-5-trifluoromethylphenyl)(6,7-methylenedioxyisoquinolin-1-yl)methanone
CAS No.:1432725-89-7
Molecular Formula:C₁₈H₉BrF₃NO₃
Molecular Weight:424.174
Hs Code.:

Synonyms:(2-bromo-5-trifluoromethylphenyl)(6,7-methylenedioxyisoquinolin-1-yl)methanone

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Chemical Property of (2-bromo-5-trifluoromethylphenyl)(6,7-methylenedioxyisoquinolin-1-yl)methanone

Chemical Property:

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Technology Process of (2-bromo-5-trifluoromethylphenyl)(6,7-methylenedioxyisoquinolin-1-yl)methanone

There total 3 articles about (2-bromo-5-trifluoromethylphenyl)(6,7-methylenedioxyisoquinolin-1-yl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

: 1432725-73-9
(2-bromo-5-trifluoromethylphenyl)(6,7-methylenedioxyisoquinolin-1-yl)acetonitrile

: 1432725-89-7
(2-bromo-5-trifluoromethylphenyl)(6,7-methylenedioxyisoquinolin-1-yl)methanone

Guidance literature:: (2-bromo-5-trifluoromethylphenyl)(6,7-methylenedioxyisoquinolin-1-yl)acetonitrile; With sodium hydride; In tetrahydrofuran; at 20 ℃; for 1h;

With oxygen; In tetrahydrofuran; at 20 ℃; for 3h;
DOI:10.1021/jo400645g

Reference yield:

: 1432725-49-9
1-iodo-6,7-(methylenedioxy)isoquinoline

: 1432725-89-7
(2-bromo-5-trifluoromethylphenyl)(6,7-methylenedioxyisoquinolin-1-yl)methanone

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium amide / tetrahydrofuran / Reflux; Inert atmosphere; Cooling with ice

2.1: sodium hydride / tetrahydrofuran / 1 h / 20 °C

2.2: 3 h / 20 °C

With sodium hydride; sodium amide; In tetrahydrofuran;
DOI:10.1021/jo400645g

Reference yield:

: 24188-76-9
[1,3]dioxolo[4,5-g]isoquinolin-5(6H)-one

: 1432725-89-7
(2-bromo-5-trifluoromethylphenyl)(6,7-methylenedioxyisoquinolin-1-yl)methanone

Guidance literature:: Multi-step reaction with 3 steps

1.1: trifluoromethylsulfonic anhydride; pyridine / acetonitrile / 2 h / 20 °C / Cooling with ice; Inert atmosphere

1.2: 20 °C / Inert atmosphere

2.1: sodium amide / tetrahydrofuran / Reflux; Inert atmosphere; Cooling with ice

3.1: sodium hydride / tetrahydrofuran / 1 h / 20 °C

3.2: 3 h / 20 °C

With pyridine; trifluoromethylsulfonic anhydride; sodium hydride; sodium amide; In tetrahydrofuran; acetonitrile;
DOI:10.1021/jo400645g