6-hydroxy-7-methoxy-2-(2-methoxyphenylsulfonyl)-1,2,3,4-tetrahydroisoquinoline

Base Information

Chemical Name:6-hydroxy-7-methoxy-2-(2-methoxyphenylsulfonyl)-1,2,3,4-tetrahydroisoquinoline
CAS No.:1064201-51-9
Molecular Formula:C₁₇H₁₉NO₅S
Molecular Weight:349.408
Hs Code.:

Synonyms:6-hydroxy-7-methoxy-2-(2-methoxyphenylsulfonyl)-1,2,3,4-tetrahydroisoquinoline

Suppliers and Price of 6-hydroxy-7-methoxy-2-(2-methoxyphenylsulfonyl)-1,2,3,4-tetrahydroisoquinoline

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 6-hydroxy-7-methoxy-2-(2-methoxyphenylsulfonyl)-1,2,3,4-tetrahydroisoquinoline

Chemical Property:

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Technology Process of 6-hydroxy-7-methoxy-2-(2-methoxyphenylsulfonyl)-1,2,3,4-tetrahydroisoquinoline

There total 14 articles about 6-hydroxy-7-methoxy-2-(2-methoxyphenylsulfonyl)-1,2,3,4-tetrahydroisoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

: 1064201-33-7
7-methoxy-2-(2-methoxyphenylsulfonyl)-6-(triisopropylsiloxy)-1,2,3,4-tetrahydroisoquinoline

: 1064201-51-9
6-hydroxy-7-methoxy-2-(2-methoxyphenylsulfonyl)-1,2,3,4-tetrahydroisoquinoline

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 0 ℃; for 1h;
DOI:10.1002/cmdc.201300261

Reference yield: 45.0%

: 1064201-51-9
6-hydroxy-7-methoxy-2-(2-methoxyphenylsulfonyl)-1,2,3,4-tetrahydroisoquinoline

Guidance literature:

Reference yield:

: 36455-21-7
3-benzyloxy-4-methoxyphenylethylamine

: 1064201-51-9
6-hydroxy-7-methoxy-2-(2-methoxyphenylsulfonyl)-1,2,3,4-tetrahydroisoquinoline

Guidance literature:: Multi-step reaction with 7 steps

1: triethylamine / dichloromethane / 4 h / 0 - 20 °C

2: toluene-4-sulfonic acid / toluene / 4 h / 120 °C

3: sodium hydroxide / water; ethanol / 16 h / 120 °C

4: palladium 10% on activated carbon; hydrogen / methanol / 20 °C

5: 1H-imidazole / dichloromethane / 48 h / 20 °C

6: triethylamine / dichloromethane / 22 h / 20 °C

7: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h / 0 °C

With 1H-imidazole; palladium 10% on activated carbon; tetrabutyl ammonium fluoride; hydrogen; toluene-4-sulfonic acid; triethylamine; sodium hydroxide; In tetrahydrofuran; methanol; ethanol; dichloromethane; water; toluene;
DOI:10.1002/cmdc.201300261