(R)-(-)-1-(3-hydroxy-5-fluorophenyl)-1-(thiazol-2-yl)propyl methyl ether

Base Information

Chemical Name:(R)-(-)-1-(3-hydroxy-5-fluorophenyl)-1-(thiazol-2-yl)propyl methyl ether
CAS No.:153441-21-5
Molecular Formula:C₁₃H₁₄FNO₂S
Molecular Weight:267.324
Hs Code.:

Synonyms:(R)-(-)-1-(3-hydroxy-5-fluorophenyl)-1-(thiazol-2-yl)propyl methyl ether

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Chemical Property of (R)-(-)-1-(3-hydroxy-5-fluorophenyl)-1-(thiazol-2-yl)propyl methyl ether

Chemical Property:

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Technology Process of (R)-(-)-1-(3-hydroxy-5-fluorophenyl)-1-(thiazol-2-yl)propyl methyl ether

There total 5 articles about (R)-(-)-1-(3-hydroxy-5-fluorophenyl)-1-(thiazol-2-yl)propyl methyl ether which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 153441-19-1
(R)-(-)-1-<3-(benzyloxy)-5-fluorophenyl>-1-(thiazol-2-yl)propyl methyl 4ther

: 153441-21-5
(R)-(-)-1-(3-hydroxy-5-fluorophenyl)-1-(thiazol-2-yl)propyl methyl ether

Guidance literature:: With hydrogen; palladium on activated charcoal; In ethyl acetate; under 2585.7 Torr;
DOI:10.1021/jm00027a014

Reference yield:

: 153441-17-9
(R)-(+)-2-<3-(benzyloxy)-5-fluorophenyl>-2-methoxybutanal

: 153441-21-5
(R)-(-)-1-(3-hydroxy-5-fluorophenyl)-1-(thiazol-2-yl)propyl methyl ether

Guidance literature:: Multi-step reaction with 3 steps

1: Na₂SO₄, NH₃(gas) / tetrahydrofuran / Heating

2: 2,3-dichloro-5,6-dicyano-1,4-benzoquinone / benzene / 3 h / Heating

3: 67 percent / H₂ / 30percent Pd/C / ethyl acetate / 2585.7 Torr

With ammonia; hydrogen; sodium sulfate; 2,3-dicyano-5,6-dichloro-p-benzoquinone; palladium on activated charcoal; In tetrahydrofuran; ethyl acetate; benzene;
DOI:10.1021/jm00027a014

Reference yield:

: 153441-15-7
(R)-(-)-2-<3-(benzyloxy)-5-fluorophenyl>-2-methoxybutanol

: 153441-21-5
(R)-(-)-1-(3-hydroxy-5-fluorophenyl)-1-(thiazol-2-yl)propyl methyl ether

Guidance literature:: Multi-step reaction with 4 steps

1: 86 percent / DMSO, oxalyl chloride / CH₂Cl₂ / 1.25 h / -60 - 20 °C

2: Na₂SO₄, NH₃(gas) / tetrahydrofuran / Heating

3: 2,3-dichloro-5,6-dicyano-1,4-benzoquinone / benzene / 3 h / Heating

4: 67 percent / H₂ / 30percent Pd/C / ethyl acetate / 2585.7 Torr

With oxalyl dichloride; ammonia; hydrogen; dimethyl sulfoxide; sodium sulfate; 2,3-dicyano-5,6-dichloro-p-benzoquinone; palladium on activated charcoal; In tetrahydrofuran; dichloromethane; ethyl acetate; benzene;
DOI:10.1021/jm00027a014