CYTIDINE-5'-O-(1-THIOTRIPHOSPHATE), RP-ISOMER SODIUM SALT

Base Information

• Chemical Name: CYTIDINE-5'-O-(1-THIOTRIPHOSPHATE), RP-ISOMER SODIUM SALT
• CAS No.: 118353-34-7
• Molecular Formula: C₉H₁₂N₃O₁₃P₃S
• Molecular Weight: 495.194
• Mol file: 118353-34-7.mol

Synonyms:RP-CTP-ALPHA-S SODIUM SALT;SP-CTP-ALPHA-S SODIUM SALT;CYTIDINE-5’-O-(1-THIOTRIPHOSPHATE), RP-ISOMER SODIUM SALT;CYTIDINE-5’-O-(1-THIOTRIPHOSPHATE), SP-ISOMER SODIUM SALT;cytidine-5鈥?o-(1-thiotriphosphate),sp-isomer(sp-ctp-alpha-s),sodiumsalt

Chemical Property of CYTIDINE-5'-O-(1-THIOTRIPHOSPHATE), RP-ISOMER SODIUM SALT

Chemical Property:

Purity/Quality:

97% ^*data from raw suppliers

Cytidine-5'-O-(1-thiotriphosphate) lithium salt - 100mM aqueous solution ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of CYTIDINE-5'-O-(1-THIOTRIPHOSPHATE), RP-ISOMER SODIUM SALT

There total 4 articles about CYTIDINE-5'-O-(1-THIOTRIPHOSPHATE), RP-ISOMER SODIUM SALT which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-Amino-1-[(3aR,4R,6R,6aR)-2-methoxy-6-(4-oxo-4H-benzo[1,3,2]dioxaphosphinin-2-yloxymethyl)-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl]-1H-pyrimidin-2-one → C9H12N3O13P3S(4-) (118353-34-7)

Guidance literature:

Multi-step reaction with 3 steps

1: bis(tri-n-butylammonium) pyrophosphate, tri-n-butylamine / dimethylformamide / 0.17 h

2: sulfur / dimethylformamide / 0.17 h

3: 1.) H₂O, 2.) glacial acetic acid / 1.) 30 min, 2.) room temp., 1 h

With tributyl-amine; water; bis(tri-n-butylammonium) pyrophosphate; sulfur; acetic acid; In N,N-dimethyl-formamide;

DOI:10.1021/jo00264a024

Reference yield:

C11H14N3O13P3(2-) → C9H12N3O13P3S(4-) (118353-34-7)

Guidance literature:

Multi-step reaction with 2 steps

1: sulfur / dimethylformamide / 0.17 h

2: 1.) H₂O, 2.) glacial acetic acid / 1.) 30 min, 2.) room temp., 1 h

With water; sulfur; acetic acid; In N,N-dimethyl-formamide;

DOI:10.1021/jo00264a024

Reference yield:

2',3'-O-(methoxymethylidene)cytidine (16628-82-3) → C9H12N3O13P3S(4-) (118353-34-7)

Guidance literature:

Multi-step reaction with 4 steps

1: pyridine / dioxane; dimethylformamide / 0.17 h

2: bis(tri-n-butylammonium) pyrophosphate, tri-n-butylamine / dimethylformamide / 0.17 h

3: sulfur / dimethylformamide / 0.17 h

4: 1.) H₂O, 2.) glacial acetic acid / 1.) 30 min, 2.) room temp., 1 h

With pyridine; tributyl-amine; water; bis(tri-n-butylammonium) pyrophosphate; sulfur; acetic acid; In 1,4-dioxane; N,N-dimethyl-formamide;

DOI:10.1021/jo00264a024

upstream raw materials:

C₁₁H₁₄N₃O₁₃P₃S^(2-)

2',3'-O-(methoxymethylidene)cytidine

Refernces