5-(4-amino-2-(3-(5-chloropyridin-3-yl)phenyl)-5-methyl-2H-imidazol-2-yl)-1-ethyl-3-methylpyridin-2(1H)-one

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Chemical Name:5-(4-amino-2-(3-(5-chloropyridin-3-yl)phenyl)-5-methyl-2H-imidazol-2-yl)-1-ethyl-3-methylpyridin-2(1H)-one
CAS No.:1260215-64-2
Molecular Formula:C₂₃H₂₂ClN₅O
Molecular Weight:419.914
Hs Code.:

Synonyms:5-(4-amino-2-(3-(5-chloropyridin-3-yl)phenyl)-5-methyl-2H-imidazol-2-yl)-1-ethyl-3-methylpyridin-2(1H)-one

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Chemical Property of 5-(4-amino-2-(3-(5-chloropyridin-3-yl)phenyl)-5-methyl-2H-imidazol-2-yl)-1-ethyl-3-methylpyridin-2(1H)-one

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Technology Process of 5-(4-amino-2-(3-(5-chloropyridin-3-yl)phenyl)-5-methyl-2H-imidazol-2-yl)-1-ethyl-3-methylpyridin-2(1H)-one

There total 6 articles about 5-(4-amino-2-(3-(5-chloropyridin-3-yl)phenyl)-5-methyl-2H-imidazol-2-yl)-1-ethyl-3-methylpyridin-2(1H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 28.0%

: 872041-85-5
(5-chloro-3-pyridyl)boronic acid

: 1260215-65-3
5-(4-amino-2-(3-bromophenyl)-5-methyl-2H-imidazol-2-yl)-1-ethyl-3-methylpyridin-2(1H)-one

: 1260215-64-2
5-(4-amino-2-(3-(5-chloropyridin-3-yl)phenyl)-5-methyl-2H-imidazol-2-yl)-1-ethyl-3-methylpyridin-2(1H)-one

Guidance literature:: With potassium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In 1,4-dioxane; water; at 130 ℃; for 0.25h; Microwave irradiation;

Reference yield:

: 760207-87-2
5-bromo-2-methoxy-3-methylpyridine

: 1260215-64-2
5-(4-amino-2-(3-(5-chloropyridin-3-yl)phenyl)-5-methyl-2H-imidazol-2-yl)-1-ethyl-3-methylpyridin-2(1H)-one

Guidance literature:: Multi-step reaction with 6 steps

1.1: n-butyllithium / diethyl ether / 0.33 h / -78 °C / Inert atmosphere

1.2: 0.5 h / -78 °C

2.1: methanol / 31 h / 20 - 60 °C / Inert atmosphere

3.1: ammonia / methanol / 1 h / 100 °C / Sealed vial; Microwave irradiation

4.1: hydrogenchloride / water; tetrahydrofuran / 0.75 h / 100 °C / Sealed vial; Microwave irradiation

5.1: sodium hydride / N,N-dimethyl-formamide / 0.42 h / 0 - 20 °C / Inert atmosphere

5.2: 0 °C

6.1: potassium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane; water / 0.25 h / 130 °C / Microwave irradiation

With hydrogenchloride; n-butyllithium; ammonia; sodium hydride; potassium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In tetrahydrofuran; 1,4-dioxane; methanol; diethyl ether; water; N,N-dimethyl-formamide;

Reference yield:

: 6952-59-6
3-cyanobromobenzene

: 1260215-64-2
5-(4-amino-2-(3-(5-chloropyridin-3-yl)phenyl)-5-methyl-2H-imidazol-2-yl)-1-ethyl-3-methylpyridin-2(1H)-one

Guidance literature:: Multi-step reaction with 6 steps

1.1: n-butyllithium / diethyl ether / 0.33 h / -78 °C / Inert atmosphere

1.2: 0.5 h / -78 °C

2.1: methanol / 31 h / 20 - 60 °C / Inert atmosphere

3.1: ammonia / methanol / 1 h / 100 °C / Sealed vial; Microwave irradiation

4.1: hydrogenchloride / water; tetrahydrofuran / 0.75 h / 100 °C / Sealed vial; Microwave irradiation

5.1: sodium hydride / N,N-dimethyl-formamide / 0.42 h / 0 - 20 °C / Inert atmosphere

5.2: 0 °C

6.1: potassium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane; water / 0.25 h / 130 °C / Microwave irradiation

With hydrogenchloride; n-butyllithium; ammonia; sodium hydride; potassium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In tetrahydrofuran; 1,4-dioxane; methanol; diethyl ether; water; N,N-dimethyl-formamide;