2-{[methyl-(3-phenyl-prop-2-ynyl)-carbamoyl]-methylene}-malonic acid diethyl ester

Base Information

Chemical Name:2-{[methyl-(3-phenyl-prop-2-ynyl)-carbamoyl]-methylene}-malonic acid diethyl ester
CAS No.:431911-38-5
Molecular Formula:C₁₉H₂₁NO₅
Molecular Weight:343.379
Hs Code.:

Synonyms:2-{[methyl-(3-phenyl-prop-2-ynyl)-carbamoyl]-methylene}-malonic acid diethyl ester

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Chemical Property of 2-{[methyl-(3-phenyl-prop-2-ynyl)-carbamoyl]-methylene}-malonic acid diethyl ester

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Technology Process of 2-{[methyl-(3-phenyl-prop-2-ynyl)-carbamoyl]-methylene}-malonic acid diethyl ester

There total 1 articles about 2-{[methyl-(3-phenyl-prop-2-ynyl)-carbamoyl]-methylene}-malonic acid diethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: 34706-60-0
N-methyl-3-phenylprop-2-yn-1-amine

: 431911-73-8
β,β-bis(ethoxycarbonyl)acrylic acid

: 431911-38-5
2-{[methyl-(3-phenyl-prop-2-ynyl)-carbamoyl]-methylene}-malonic acid diethyl ester

Guidance literature:: With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; tert-butyl alcohol; In tetrahydrofuran; at 0 - 20 ℃; for 17h;
DOI:10.1021/jo016159r

Reference yield: 84.0%

: 431911-38-5
2-{[methyl-(3-phenyl-prop-2-ynyl)-carbamoyl]-methylene}-malonic acid diethyl ester

: 2-{4-[1-Bromo-1-phenyl-meth-(Z)-ylidene]-1-methyl-2-oxo-pyrrolidin-3-yl}-malonic acid diethyl ester

Guidance literature:: 2-{[methyl-(3-phenyl-prop-2-ynyl)-carbamoyl]-methylene}-malonic acid diethyl ester; With tetrahydrofuran; zinc dibromide; In dichloromethane; at -40 ℃; for 16h;

With triethylamine; Further stages.;
DOI:10.1021/jo016159r

Reference yield: 64.0%

: 431911-38-5
2-{[methyl-(3-phenyl-prop-2-ynyl)-carbamoyl]-methylene}-malonic acid diethyl ester

: 2-{4-[1-Chloro-1-phenyl-meth-(Z)-ylidene]-1-methyl-2-oxo-pyrrolidin-3-yl}-malonic acid diethyl ester

Guidance literature:: 2-{[methyl-(3-phenyl-prop-2-ynyl)-carbamoyl]-methylene}-malonic acid diethyl ester; With zinc(II) chloride; In dichloromethane; at -40 ℃; for 18h;

With triethylamine; Further stages.;
DOI:10.1021/jo016159r