1-ethynylcyclohexyl (benzyl) carbonate

Base Information

• Chemical Name: 1-ethynylcyclohexyl (benzyl) carbonate
• CAS No.: 1446451-73-5
• Molecular Formula: C₁₆H₁₈O₃
• Molecular Weight: 258.317
• Mol file: 1446451-73-5.mol

Synonyms:1-ethynylcyclohexyl (benzyl) carbonate

Chemical Property of 1-ethynylcyclohexyl (benzyl) carbonate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-ethynylcyclohexyl (benzyl) carbonate

There total 2 articles about 1-ethynylcyclohexyl (benzyl) carbonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-Ethynylcyclohexan-1-ol (78-27-3) + benzyl chloroformate (501-53-1,94274-21-2) → 1-ethynylcyclohexyl (benzyl) carbonate (1446451-73-5)

Guidance literature:

1-Ethynylcyclohexan-1-ol; With sodium hydride; In N,N-dimethyl-formamide; for 0.166667h; Cooling with ice;

benzyl chloroformate; In N,N-dimethyl-formamide; at 20 ℃;

DOI:10.3762/bjoc.12.197

Reference yield:

1-ethynyl cyclohexyl(4-nitrophenyl)carbonate + benzyl alcohol (100-51-6,185532-71-2) → 1-ethynylcyclohexyl (benzyl) carbonate (1446451-73-5)

Guidance literature:

benzyl alcohol; With dmap; In dichloromethane; for 0.5h; Inert atmosphere;

1-ethynyl cyclohexyl(4-nitrophenyl)carbonate; In dichloromethane; for 3h; Inert atmosphere;

DOI:10.1021/acs.joc.9b00016

Reference yield: 86.0%

1-ethynylcyclohexyl (benzyl) carbonate (1446451-73-5) + diazomethyl-trimethyl-silane (18107-18-1) → C17H20O3 (1446452-33-0)

Guidance literature:

With styrene; chloro(1,5-cyclooctadiene)(pentamethylcyclopentadiene)ruthenium(II); In methanol; diethyl ether; at 20 ℃; for 2h; Schlenk technique; Inert atmosphere;

DOI:10.1002/chem.201203796

upstream raw materials:

1-Ethynylcyclohexan-1-ol

benzyl chloroformate

benzyl alcohol

Downstream raw materials:

C₂₀H₂₈O₃Si

C₂₀H₂₈O₃Si

C₁₇H₂₀O₃