Z-4-AMINO-3-HYDROXYBUTYRIC ACID

Base Information

• Chemical Name: Z-4-AMINO-3-HYDROXYBUTYRIC ACID
• CAS No.: 118125-41-0
• Molecular Formula: C₁₂H₁₅NO₅
• Molecular Weight: 253.255
• Mol file: 118125-41-0.mol

Synonyms:Butanoicacid, 3-hydroxy-4-[[(phenylmethoxy)carbonyl]amino]-, (?à)-;3-Hydroxy-4-(benzyloxycarbonylamino)butanoic acid

Chemical Property of Z-4-AMINO-3-HYDROXYBUTYRIC ACID

Chemical Property:

• PSA: 95.86000
• LogP: 1.13930

Purity/Quality:

98% ^*data from raw suppliers

Z-DL-4-amino-3-hydroxybutyric acid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Z-4-AMINO-3-HYDROXYBUTYRIC ACID

There total 24 articles about Z-4-AMINO-3-HYDROXYBUTYRIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

N-(Benzyloxycarbonyloxy)succinimide (13139-17-8) + (R)-4-Amino-3-hydroxybutanoic acid (7013-07-2,352-21-6) → (R)-4-<(Benzyloxycarbonyl)amino>-3-hydroxybutanoic acid (80503-94-2,118125-41-0)

Guidance literature:

With sodium hydrogencarbonate; In water; acetone; at 23 ℃; Schlenk technique; Inert atmosphere;

DOI:10.1002/cmdc.201402508

Reference yield: 86.0%

methyl (R)-3-acetoxy-4-[(benzyloxycarbonyl)amino]butanoate (180520-94-9) → (R)-4-<(Benzyloxycarbonyl)amino>-3-hydroxybutanoic acid (80503-94-2,118125-41-0)

Guidance literature:

With hydrogenchloride; water; at 50 ℃; for 19h;

DOI:10.1021/jo960468d

Reference yield: 84.0%

DL-4-amino-3-hydroxybutyric acid (924-49-2,352-21-6) + benzyl chloroformate (501-53-1,94274-21-2) → 4-<(Benzyloxycarbonyl)amino>-3-hydroxybutanoic acid (83349-20-6,118125-41-0)

Guidance literature:

With sodium hydroxide; In 1,4-dioxane; at 0 - 5 ℃;

upstream raw materials:

DL-4-amino-3-hydroxybutyric acid

benzyl chloroformate

(R)-4-(tert-butyloxycarbonyl)amino-3-hydroxybutanoic acid

(1'R)-4-<(Benzyloxycarbonyl)amino>-3-hydroxybutanoic acid 2'-hydroxy-1',2',2'-triphenylethyl ester

Downstream raw materials:

methyl (RS)-<4-(benzyloxycarbonyl)amino>-3-hydroxybutyrate

(RS)-<1-(benzyloxycarbonyl)amino>-butan-2,4-diol

N-Benzyloxycarbonyl-4-amino-3-benzyloxybutyric acid

p-Nitrobenzyl (N-benzyloxycarbonyl-4-amino-3-benzyloxy)butyrate