tert-butyl (2-(3-(2-cyclohexylethyl)phenyl)-2-oxoethyl)terephthalate

Base Information

• Chemical Name: tert-butyl (2-(3-(2-cyclohexylethyl)phenyl)-2-oxoethyl)terephthalate
• CAS No.: 1307310-03-7
• Molecular Formula: C₂₈H₃₄O₅
• Molecular Weight: 450.575
• Mol file: 1307310-03-7.mol

Synonyms:tert-butyl (2-(3-(2-cyclohexylethyl)phenyl)-2-oxoethyl)terephthalate

Chemical Property of tert-butyl (2-(3-(2-cyclohexylethyl)phenyl)-2-oxoethyl)terephthalate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of tert-butyl (2-(3-(2-cyclohexylethyl)phenyl)-2-oxoethyl)terephthalate

There total 5 articles about tert-butyl (2-(3-(2-cyclohexylethyl)phenyl)-2-oxoethyl)terephthalate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

2-bromo-1-(3-(2-cyclohexylethyl)phenyl)ethanone (1307310-02-6) + terephthalic acid mono-tert-butyl ester (20576-82-3) → tert-butyl (2-(3-(2-cyclohexylethyl)phenyl)-2-oxoethyl)terephthalate (1307310-03-7)

Guidance literature:

terephthalic acid mono-tert-butyl ester; With caesium carbonate; In ethanol; at 20 ℃; for 0.1h; Sonication; Inert atmosphere;

2-bromo-1-(3-(2-cyclohexylethyl)phenyl)ethanone; In N,N-dimethyl-formamide; at 20 ℃; for 12h; Inert atmosphere;

DOI:10.1021/jm2001053

Reference yield:

1-(3-(2-cyclohexylethyl)phenyl)ethanone (1307310-01-5) → tert-butyl (2-(3-(2-cyclohexylethyl)phenyl)-2-oxoethyl)terephthalate (1307310-03-7)

Guidance literature:

Multi-step reaction with 2 steps

1.1: bromine / chloroform / 40 °C / Inert atmosphere

2.1: caesium carbonate / ethanol / 0.1 h / 20 °C / Sonication; Inert atmosphere

2.2: 12 h / 20 °C / Inert atmosphere

With bromine; caesium carbonate; In ethanol; chloroform;

DOI:10.1021/jm2001053

Reference yield:

vinylcyclohexane (695-12-5,25498-06-0) → tert-butyl (2-(3-(2-cyclohexylethyl)phenyl)-2-oxoethyl)terephthalate (1307310-03-7)

Guidance literature:

Multi-step reaction with 3 steps

1.1: 9-bora-bicyclo[3.3.1]nonane / 12 h

1.2: 1 h / Reflux

2.1: bromine / chloroform / 40 °C / Inert atmosphere

3.1: caesium carbonate / ethanol / 0.1 h / 20 °C / Sonication; Inert atmosphere

3.2: 12 h / 20 °C / Inert atmosphere

With bromine; caesium carbonate; 9-bora-bicyclo[3.3.1]nonane; In ethanol; chloroform; 1.1: Hydroboration reaction;

DOI:10.1021/jm2001053

upstream raw materials:

1-(3-(2-cyclohexylethyl)phenyl)ethanone

2-bromo-1-(3-(2-cyclohexylethyl)phenyl)ethanone

terephthalic acid mono-tert-butyl ester

vinylcyclohexane

Downstream raw materials:

C₂₄H₂₆N₂O₂

tert-butyl 4-(4-(3-(2-cyclohexylethyl)phenyl)-1H-imidazol-2-yl)benzoate

(S)-1-(4-(4-(3-(2-cyclohexylethyl)phenyl)-1H-imidazol-2-yl)benzoyl)pyrrolidine-2-carbonitrile

(S)-1-(4-(4-(3-(2-cyclohexylethyl)phenyl)-1H-imidazol-2-yl)benzoyl)pyrrolidine-2-carboximidamide hydrochloride

Refernces