(R)-benzyl 2-((2R,4S,6S)-tetrahydro-5,5-dimethyl-6-((3R,4S)-4-hydroxy-3-methyl-5-(6-methyl-2-methyloxycarbonyl-3,5-bistriisopropylsilyloxyphenyl)-2-oxopentyl)-4-tert-butyldimethylsilyloxy-2H-pyran-2-yl)-2-methoxyacetate

Base Information

Chemical Name:(R)-benzyl 2-((2R,4S,6S)-tetrahydro-5,5-dimethyl-6-((3R,4S)-4-hydroxy-3-methyl-5-(6-methyl-2-methyloxycarbonyl-3,5-bistriisopropylsilyloxyphenyl)-2-oxopentyl)-4-tert-butyldimethylsilyloxy-2H-pyran-2-yl)-2-methoxyacetate
CAS No.:1213265-24-7
Molecular Formula:C₅₆H₉₆O₁₁Si₃
Molecular Weight:1029.63
Hs Code.:

(R)-benzyl 2-((2R,4S,6S)-tetrahydro-5,5-dimethyl-6-((3R,4S)-4-hydroxy-3-methyl-5-(6-methyl-2-methyloxycarbonyl-3,5-bistriisopropylsilyloxyphenyl)-2-oxopentyl)-4-tert-butyldimethylsilyloxy-2H-pyran-2-yl)-2-methoxyacetate

Synonyms:(R)-benzyl 2-((2R,4S,6S)-tetrahydro-5,5-dimethyl-6-((3R,4S)-4-hydroxy-3-methyl-5-(6-methyl-2-methyloxycarbonyl-3,5-bistriisopropylsilyloxyphenyl)-2-oxopentyl)-4-tert-butyldimethylsilyloxy-2H-pyran-2-yl)-2-methoxyacetate

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Chemical Property of (R)-benzyl 2-((2R,4S,6S)-tetrahydro-5,5-dimethyl-6-((3R,4S)-4-hydroxy-3-methyl-5-(6-methyl-2-methyloxycarbonyl-3,5-bistriisopropylsilyloxyphenyl)-2-oxopentyl)-4-tert-butyldimethylsilyloxy-2H-pyran-2-yl)-2-methoxyacetate

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Technology Process of (R)-benzyl 2-((2R,4S,6S)-tetrahydro-5,5-dimethyl-6-((3R,4S)-4-hydroxy-3-methyl-5-(6-methyl-2-methyloxycarbonyl-3,5-bistriisopropylsilyloxyphenyl)-2-oxopentyl)-4-tert-butyldimethylsilyloxy-2H-pyran-2-yl)-2-methoxyacetate

There total 1 articles about (R)-benzyl 2-((2R,4S,6S)-tetrahydro-5,5-dimethyl-6-((3R,4S)-4-hydroxy-3-methyl-5-(6-methyl-2-methyloxycarbonyl-3,5-bistriisopropylsilyloxyphenyl)-2-oxopentyl)-4-tert-butyldimethylsilyloxy-2H-pyran-2-yl)-2-methoxyacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1186291-38-2
methyl 2,4-bistriisopropylsilyloxy-5-methyl-6-(2-oxoethyl)benzoate

: 1213265-22-5
(2S,4S,6R)-6-((1S)-1-benzyloxycarbonyl-1-methoxymethyl)-3,3-dimethyl-2-(2-oxobutyl)-4-tert-butyldimethylsilyloxytetrahydropyran

: 1213265-24-7
(R)-benzyl 2-((2R,4S,6S)-tetrahydro-5,5-dimethyl-6-((3R,4S)-4-hydroxy-3-methyl-5-(6-methyl-2-methyloxycarbonyl-3,5-bistriisopropylsilyloxyphenyl)-2-oxopentyl)-4-tert-butyldimethylsilyloxy-2H-pyran-2-yl)-2-methoxyacetate

Guidance literature:: (2S,4S,6R)-6-((1S)-1-benzyloxycarbonyl-1-methoxymethyl)-3,3-dimethyl-2-(2-oxobutyl)-4-tert-butyldimethylsilyloxytetrahydropyran; With phenylborondichloride; In dichloromethane; at -78 ℃; for 0.333333h; Inert atmosphere;

With N-ethyl-N,N-diisopropylamine; In dichloromethane; at -78 ℃; for 1h; Inert atmosphere;

methyl 2,4-bistriisopropylsilyloxy-5-methyl-6-(2-oxoethyl)benzoate; diastereoselective reaction; Further stages;
DOI:10.1021/ol1000389

Reference yield:

: 1213265-24-7
(R)-benzyl 2-((2R,4S,6S)-tetrahydro-5,5-dimethyl-6-((3R,4S)-4-hydroxy-3-methyl-5-(6-methyl-2-methyloxycarbonyl-3,5-bistriisopropylsilyloxyphenyl)-2-oxopentyl)-4-tert-butyldimethylsilyloxy-2H-pyran-2-yl)-2-methoxyacetate

: 1213265-27-0
(R)-benzyl 2-((2R,4S,6S)-tetrahydro-6-((2R,3R,4S)-2,4-bishydroxy-3-methyl-5-(6-methyl-2-methyloxycarbonyl-3,5-bistriisopropylsilyloxyphenyl)-pentyl)-5,5-dimethyl-4-tert-butyldimethylsilyloxy-2H-pyran-2-yl)-2-methoxyacetate

Guidance literature:: With sodium tetrahydroborate; triethyl borane; In tetrahydrofuran; methanol; hexane; at -70 ℃; for 16h; Inert atmosphere;
DOI:10.1021/ol1000389