C₅₉H₈₂N₁₂O₁₃

Base Information

• Chemical Name: C₅₉H₈₂N₁₂O₁₃
• CAS No.: 90600-45-6
• Molecular Formula: C₅₉H₈₂N₁₂O₁₃
• Molecular Weight: 1167.37
• Mol file: 90600-45-6.mol

Synonyms:C₅₉H₈₂N₁₂O₁₃

Chemical Property of C₅₉H₈₂N₁₂O₁₃

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₅₉H₈₂N₁₂O₁₃

There total 11 articles about C₅₉H₈₂N₁₂O₁₃ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-(tert-butoxycarbonyl)-L-proline (15761-39-4,59433-50-0) → C59H82N12O13 (90600-45-6)

Guidance literature:

Multi-step reaction with 7 steps

1: 1) N-methylmorpholine, ethyl chloroformate, 2) N-methylmorpholine / 1) THF, 10 min, 2) DMF, 1h, ice bath then room temperature overnight

2: 95 percent / 4.1M hydrogen chloride / dioxane / 2 h / Ambient temperature

4: 97 percent / 4.1M hydrogen chloride / dioxane / 2 h / Ambient temperature

5: 1) N-methylmorpholine, ethyl chloroformate, 2) N-methylmorpholine / 1) THF, 10 min, 2) DMF, 1h, ice bath then room temperature overnight

6: 92 percent / 4.1M hydrogen chloride / dioxane / 2 h / Ambient temperature

7: 1) DCC, 2) N-methylmorpholine / 1) DMF, 20 min, 2) chloroform, 0 deg C, 3 h

With 4-methyl-morpholine; hydrogenchloride; chloroformic acid ethyl ester; dicyclohexyl-carbodiimide; In 1,4-dioxane;

DOI:10.1246/bcsj.57.819

Reference yield:

Boc-Ile-OH*DCHA (16948-00-8,55780-92-2) → C59H82N12O13 (90600-45-6)

Guidance literature:

Multi-step reaction with 9 steps

2: 96 percent / 4.1M hydrogen chloride / dioxane / 2 h / Ambient temperature

3: 1) N-methylmorpholine, ethyl chloroformate, 2) N-methylmorpholine / 1) THF, 10 min, 2) DMF, 1h, ice bath then room temperature overnight

4: 95 percent / 4.1M hydrogen chloride / dioxane / 2 h / Ambient temperature

6: 97 percent / 4.1M hydrogen chloride / dioxane / 2 h / Ambient temperature

7: 1) N-methylmorpholine, ethyl chloroformate, 2) N-methylmorpholine / 1) THF, 10 min, 2) DMF, 1h, ice bath then room temperature overnight

8: 92 percent / 4.1M hydrogen chloride / dioxane / 2 h / Ambient temperature

9: 1) DCC, 2) N-methylmorpholine / 1) DMF, 20 min, 2) chloroform, 0 deg C, 3 h

With 4-methyl-morpholine; hydrogenchloride; chloroformic acid ethyl ester; dicyclohexyl-carbodiimide; In 1,4-dioxane;

DOI:10.1246/bcsj.57.819

Reference yield:

benzyl (S)-2-((2S,3S)-2-amino-3-methylpentanoylamino)-3-methylbutyrate hydrochloride → C59H82N12O13 (90600-45-6)

Guidance literature:

Multi-step reaction with 9 steps

2: 96 percent / 4.1M hydrogen chloride / dioxane / 2 h / Ambient temperature

3: 1) N-methylmorpholine, ethyl chloroformate, 2) N-methylmorpholine / 1) THF, 10 min, 2) DMF, 1h, ice bath then room temperature overnight

4: 95 percent / 4.1M hydrogen chloride / dioxane / 2 h / Ambient temperature

6: 97 percent / 4.1M hydrogen chloride / dioxane / 2 h / Ambient temperature

7: 1) N-methylmorpholine, ethyl chloroformate, 2) N-methylmorpholine / 1) THF, 10 min, 2) DMF, 1h, ice bath then room temperature overnight

8: 92 percent / 4.1M hydrogen chloride / dioxane / 2 h / Ambient temperature

9: 1) DCC, 2) N-methylmorpholine / 1) DMF, 20 min, 2) chloroform, 0 deg C, 3 h

With 4-methyl-morpholine; hydrogenchloride; chloroformic acid ethyl ester; dicyclohexyl-carbodiimide; In 1,4-dioxane;

DOI:10.1246/bcsj.57.819

upstream raw materials:

N^α-benzyloxycarbonyl-N^G-nitroarginylglycine

1-(tert-butoxycarbonyl)-L-proline

Boc-Ile-OH*DCHA

(S)-2-[(S)-1-Benzyl-2-((S)-2-{(1S,2S)-1-[(1S,2S)-1-((S)-1-benzyloxycarbonyl-2-methyl-propylcarbamoyl)-2-methyl-butylcarbamoyl]-2-methyl-butylcarbamoyl}-pyrrolidin-1-yl)-2-oxo-ethylcarbamoyl]-pyrrolidine-1-carboxylic acid tert-butyl ester