2,2,2-trifluoroacetic acid; N-({6-amino-1H-pyrrolo[3,2-c]pyridin-2-yl}methyl)-4-benzylpiperidine-1-carboxamide

Base Information

• Chemical Name: 2,2,2-trifluoroacetic acid; N-({6-amino-1H-pyrrolo[3,2-c]pyridin-2-yl}methyl)-4-benzylpiperidine-1-carboxamide
• CAS No.: 1392002-52-6
• Molecular Formula: C₂HF₃O₂*C₂₁H₂₅N₅O
• Molecular Weight: 477.486
• Mol file: 1392002-52-6.mol

Synonyms:2,2,2-trifluoroacetic acid; N-({6-amino-1H-pyrrolo[3,2-c]pyridin-2-yl}methyl)-4-benzylpiperidine-1-carboxamide

Chemical Property of 2,2,2-trifluoroacetic acid; N-({6-amino-1H-pyrrolo[3,2-c]pyridin-2-yl}methyl)-4-benzylpiperidine-1-carboxamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2,2,2-trifluoroacetic acid; N-({6-amino-1H-pyrrolo[3,2-c]pyridin-2-yl}methyl)-4-benzylpiperidine-1-carboxamide

There total 3 articles about 2,2,2-trifluoroacetic acid; N-({6-amino-1H-pyrrolo[3,2-c]pyridin-2-yl}methyl)-4-benzylpiperidine-1-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 3.0%

4-benzyl-N-{[6-(benzylamino)-1H-pyrrolo[3,2-c]pyridin-2-yl]methyl}piperidine-1-carboxamide (1392003-17-6) + trifluoroacetic acid (76-05-1) → 2,2,2-trifluoroacetic acid; N-({6-amino-1H-pyrrolo[3,2-c]pyridin-2-yl}methyl)-4-benzylpiperidine-1-carboxamide (1392002-52-6)

Guidance literature:

In dichloromethane; for 72h;

Reference yield:

2-chloro-4-amino-5-iodopyridine (800402-12-4) → 2,2,2-trifluoroacetic acid; N-({6-amino-1H-pyrrolo[3,2-c]pyridin-2-yl}methyl)-4-benzylpiperidine-1-carboxamide (1392002-52-6)

Guidance literature:

Multi-step reaction with 3 steps

1.1: potassium carbonate / ISOPROPYLAMIDE / 2 h / 190 °C / Microwave irradiation

2.1: triethylamine; copper(l) iodide / bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide / 1.5 h / 100 °C

2.2: 0.5 h / 50 °C

3.1: dichloromethane / 72 h

With copper(l) iodide; potassium carbonate; triethylamine; bis-triphenylphosphine-palladium(II) chloride; In dichloromethane; ISOPROPYLAMIDE; N,N-dimethyl-formamide;

Reference yield:

2-N-benzyl-5-iodopyridine-2,4-diamine (1392003-16-5) → 2,2,2-trifluoroacetic acid; N-({6-amino-1H-pyrrolo[3,2-c]pyridin-2-yl}methyl)-4-benzylpiperidine-1-carboxamide (1392002-52-6)

Guidance literature:

Multi-step reaction with 2 steps

1.1: triethylamine; copper(l) iodide / bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide / 1.5 h / 100 °C

1.2: 0.5 h / 50 °C

2.1: dichloromethane / 72 h

With copper(l) iodide; triethylamine; bis-triphenylphosphine-palladium(II) chloride; In dichloromethane; N,N-dimethyl-formamide;

upstream raw materials:

4-benzyl-N-{[6-(benzylamino)-1H-pyrrolo[3,2-c]pyridin-2-yl]methyl}piperidine-1-carboxamide

trifluoroacetic acid

2-chloro-4-amino-5-iodopyridine

2-N-benzyl-5-iodopyridine-2,4-diamine