8-Azabicyclo[3.2.1]octane-3-carbonyl chloride, 8-methyl-, exo- (9CI)

Base Information

• Chemical Name: 8-Azabicyclo[3.2.1]octane-3-carbonyl chloride, 8-methyl-, exo- (9CI)
• CAS No.: 117843-59-1
• Molecular Formula: C₉H₁₄ClNO
• Molecular Weight: 187.669
• Mol file: 117843-59-1.mol

Synonyms:8-Azabicyclo[3.2.1]octane-3-carbonyl chloride, 8-methyl-, exo- (9CI)

Chemical Property of 8-Azabicyclo[3.2.1]octane-3-carbonyl chloride, 8-methyl-, exo- (9CI)

Chemical Property:

• PSA: 20.31000
• LogP: 1.56250

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 8-Azabicyclo[3.2.1]octane-3-carbonyl chloride, 8-methyl-, exo- (9CI)

There total 1 articles about 8-Azabicyclo[3.2.1]octane-3-carbonyl chloride, 8-methyl-, exo- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3β-tropane-3-carboxylic acid (117843-58-0) → tropane-3-carbonyl chloride (117843-59-1)

Guidance literature:

With thionyl chloride; In chloroform; for 3h; Heating;

DOI:10.1002/jhet.5570440629

Reference yield:

tropane-3-carbonyl chloride (117843-59-1) → (1S,3S,5R)-3-(2-Benzylsulfanyl-4-fluoro-benzoyl)-8-aza-bicyclo[3.2.1]octane-8-carbonitrile

Guidance literature:

Multi-step reaction with 3 steps

1: Friedel-Crafts acylation

3: 49 percent / tetrahydrofuran / 0 °C

In tetrahydrofuran;

DOI:10.1016/0040-4039(93)88095-Z

Reference yield:

tropane-3-carbonyl chloride (117843-59-1) → (1S,3S,5R)-3-(2,4-Difluoro-benzoyl)-8-aza-bicyclo[3.2.1]octane-8-carbonitrile

Guidance literature:

Multi-step reaction with 2 steps

1: Friedel-Crafts acylation

DOI:10.1016/0040-4039(93)88095-Z

upstream raw materials:

3β-tropane-3-carboxylic acid