C₂₉H₃₂F₃N₃O₅

Base Information

Chemical Name:C₂₉H₃₂F₃N₃O₅
CAS No.:1416961-38-0
Molecular Formula:C₂₉H₃₂F₃N₃O₅
Molecular Weight:559.585
Hs Code.:

C<sub>29</sub>H<sub>32</sub>F<sub>3</sub>N<sub>3</sub>O<sub>5</sub>

Synonyms:C₂₉H₃₂F₃N₃O₅

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Chemical Property of C₂₉H₃₂F₃N₃O₅

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Technology Process of C₂₉H₃₂F₃N₃O₅

There total 8 articles about C₂₉H₃₂F₃N₃O₅ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

: 1416961-27-7
methyl trans-4-[1-[[7-fluoro-2-(5-fluoro-2-methylphenylamino)-6-benzoxazolyl]acetyl]-(5S)-fluoromethyl-(2S)-pyrrolidinylmethoxy]cyclohexanecarboxylate

: 1416961-38-0
C₂₉H₃₂F₃N₃O₅

Guidance literature:: With water; sodium hydroxide; In tetrahydrofuran; at 20 ℃; for 20h;
DOI:10.1016/j.bmc.2012.11.003

Reference yield:

: 1416961-09-5
(2S)-benzyloxymethyl-1-tert-butoxycarobnyl-(5S)-fluoromethylpyrrolidine

: 1416961-38-0
C₂₉H₃₂F₃N₃O₅

Guidance literature:: Multi-step reaction with 8 steps

1: palladium 10% on activated carbon; hydrogen / methanol / 15 h

2: triphenylphosphine; di-isopropyl azodicarboxylate / 2 h / 60 °C

3: Rh/Al₂O₃; hydrogen / acetic acid; ethanol / 2.5 h / 20 °C / 8?atm

4: sodium methylate / methanol / Reflux

5: diazomethyl-trimethyl-silane / benzene; hexane / 1 h / 20 °C

6: hydrogenchloride; water / 1,4-dioxane / 3 h

7: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 72 h

8: water; sodium hydroxide / tetrahydrofuran / 20 h / 20 °C

With hydrogenchloride; di-isopropyl azodicarboxylate; palladium 10% on activated carbon; Rh/Al₂O₃; water; hydrogen; sodium methylate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; triphenylphosphine; sodium hydroxide; diazomethyl-trimethyl-silane; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; hexane; acetic acid; N,N-dimethyl-formamide; benzene; 2: |Mitsunobu Displacement;
DOI:10.1016/j.bmc.2012.11.003

Reference yield:

: C₁₈H₃₀FNO₅

: 1416961-38-0
C₂₉H₃₂F₃N₃O₅

Guidance literature:: Multi-step reaction with 4 steps

1: diazomethyl-trimethyl-silane / benzene; hexane / 1 h / 20 °C

2: hydrogenchloride; water / 1,4-dioxane / 3 h

3: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 72 h

4: water; sodium hydroxide / tetrahydrofuran / 20 h / 20 °C

With hydrogenchloride; water; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; sodium hydroxide; diazomethyl-trimethyl-silane; In tetrahydrofuran; 1,4-dioxane; hexane; N,N-dimethyl-formamide; benzene;
DOI:10.1016/j.bmc.2012.11.003