N-(5-tetrazolyl)-4-methyl-6-(4-acetylaminophenyl)-2-pyridinecarboxamide

Base Information

Chemical Name:N-(5-tetrazolyl)-4-methyl-6-(4-acetylaminophenyl)-2-pyridinecarboxamide
CAS No.:80021-04-1
Molecular Formula:C₁₆H₁₅N₇O₂
Molecular Weight:337.341
Hs Code.:

Synonyms:N-(5-tetrazolyl)-4-methyl-6-(4-acetylaminophenyl)-2-pyridinecarboxamide

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Chemical Property of N-(5-tetrazolyl)-4-methyl-6-(4-acetylaminophenyl)-2-pyridinecarboxamide

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Technology Process of N-(5-tetrazolyl)-4-methyl-6-(4-acetylaminophenyl)-2-pyridinecarboxamide

There total 10 articles about N-(5-tetrazolyl)-4-methyl-6-(4-acetylaminophenyl)-2-pyridinecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 20807-64-1
4-methyl-2-(4-nitrophenyl)pyridine

: 80021-04-1
N-(5-tetrazolyl)-4-methyl-6-(4-acetylaminophenyl)-2-pyridinecarboxamide

Guidance literature:: Multi-step reaction with 9 steps

1: 30percent aq. H₂O₂ / acetic acid / 20 h / 80 °C

2: 1.) Me₂SO₄ / 1.) 80-90 deg C, 2 h, 2.) dioxane, H₂O, RT, 30 min

3: 5 M aq. HCl / 11 h / Heating

4: H₂, AcONa / 10percent Pd/C / dimethylformamide

5: SOCl₂ / 4 h / Heating

6: pyridine / tetrahydrofuran / 3 h / Heating

7: 10percent aq. NaOH / methanol / 4.5 h / Ambient temperature

8: dimethylformamide / 1 h / Ambient temperature

9: dimethylformamide / 2 h / 60 - 70 °C

With pyridine; hydrogenchloride; sodium hydroxide; thionyl chloride; hydrogen; dihydrogen peroxide; sodium acetate; dimethyl sulfate; palladium on activated charcoal; In tetrahydrofuran; methanol; acetic acid; N,N-dimethyl-formamide;
DOI:10.1021/jm00364a026

Reference yield:

: 80021-65-4
4-methyl-2-(4-nitrophenyl)pyridine N-oxide

: 80021-04-1
N-(5-tetrazolyl)-4-methyl-6-(4-acetylaminophenyl)-2-pyridinecarboxamide

Guidance literature:: Multi-step reaction with 8 steps

1: 1.) Me₂SO₄ / 1.) 80-90 deg C, 2 h, 2.) dioxane, H₂O, RT, 30 min

2: 5 M aq. HCl / 11 h / Heating

3: H₂, AcONa / 10percent Pd/C / dimethylformamide

4: SOCl₂ / 4 h / Heating

5: pyridine / tetrahydrofuran / 3 h / Heating

6: 10percent aq. NaOH / methanol / 4.5 h / Ambient temperature

7: dimethylformamide / 1 h / Ambient temperature

8: dimethylformamide / 2 h / 60 - 70 °C

With pyridine; hydrogenchloride; sodium hydroxide; thionyl chloride; hydrogen; sodium acetate; dimethyl sulfate; palladium on activated charcoal; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;
DOI:10.1021/jm00364a026

Reference yield:

: 80021-68-7
2-cyano-4-methyl-6-(4-nitrophenyl)pyridine

: 80021-04-1
N-(5-tetrazolyl)-4-methyl-6-(4-acetylaminophenyl)-2-pyridinecarboxamide

Guidance literature:: Multi-step reaction with 7 steps

1: 5 M aq. HCl / 11 h / Heating

2: H₂, AcONa / 10percent Pd/C / dimethylformamide

3: SOCl₂ / 4 h / Heating

4: pyridine / tetrahydrofuran / 3 h / Heating

5: 10percent aq. NaOH / methanol / 4.5 h / Ambient temperature

6: dimethylformamide / 1 h / Ambient temperature

7: dimethylformamide / 2 h / 60 - 70 °C

With pyridine; hydrogenchloride; sodium hydroxide; thionyl chloride; hydrogen; sodium acetate; palladium on activated charcoal; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;
DOI:10.1021/jm00364a026